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Neuritin 1 expression in human normal tissues and its association with various human cancers
Hongchang Dong1, Xing Luo1, Yuqin Niu2
1Department of Biochemistry, The Key Laboratory of Xinjiang Endemic & Ethnic Diseases, School of Medicine, Shihezi University Shihezi 832002, Xinjiang, China.
International Journal of Clinical and Experimental Pathology
|January 16, 2020
Summary
Neuritin (Nrn1) is expressed in various human tissues and is linked to 13 cancers. Downregulation of Nrn1 correlates with improved survival in most cancer patients, suggesting its potential as a biomarker.
Area of Science:
- Molecular Biology
- Oncology
- Biochemistry
Background:
- Neuritin (Nrn1) is a known central nervous system protein.
- Its expression outside the nervous system and role in human cancers remain largely uncharacterized.
Purpose of the Study:
- To investigate the expression of Nrn1 in diverse human tissues.
- To determine the association of Nrn1 with various human cancers.
Main Methods:
- Nrn1 gene expression analyzed using Clontech Multiple Tissue cDNA panel.
- Protein detection via immunohistochemistry; subcellular localization by immunocytochemistry and western blotting.
- Cancer expression data obtained from the online tool GEPIA.
Main Results:
- Nrn1 mRNA detected in placenta, lungs, skeletal muscle, thymus, pancreas, liver, and heart.
- Nrn1 localized to plasma membrane lipid rafts in SH-SY5Y cells.
- Nrn1 downregulated in 12 cancers (e.g., BLCA, BRCA, COAD) and upregulated in DLBC.
- Downregulation of Nrn1 correlated with longer survival in 12 tumor types, excluding DLBC.
Conclusions:
- Nrn1 is expressed in multiple human tissues, localized to cell membrane lipid rafts.
- Nrn1 is significantly associated with 13 human cancers.
- Nrn1 shows potential as a biomarker and therapeutic target for these cancers.
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