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Phenytoin intoxication associated with omeprazole administration in a child with defective CYP2C9

M Marano1,2, F Nicoletti3,4, S Pro5

  • 1DEA Paediatric Intensive Care Unit, IRCCS Bambino Gesù Children's Hospital, Rome, Italy. marco.marano@opbg.net.

European Journal of Clinical Pharmacology
|January 16, 2020
PubMed

Insights

Adverse drug reactions are common in children, especially with antiepileptic drugs like phenytoin. A case study highlights phenytoin intoxication in a child with a defective CYP2C9 gene after omeprazole administration.

Area of Science:

  • Pharmacogenomics
  • Pediatric Pharmacology
  • Drug Metabolism

Background:

  • Adverse drug reactions (ADRs) are prevalent in hospitalized children, often linked to antiepileptic drugs.
  • Phenytoin, a common antiepileptic, is metabolized by CYP2C9, an enzyme encoded by a polymorphic gene.
  • Other frequently used drugs, like proton pump inhibitors, can interfere with drug metabolism pathways.

Keywords:
Adverse drug reactionsCYP2C19CYP2C9OmeprazolePhenytoin

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