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Related Experiment Video

Updated: Dec 30, 2025

Author Spotlight: Investigating the Key Factors of Obliterative Bronchiolitis After Lung Transplantation

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Published on: November 10, 2023

Expanded indications for auto-lung transplant technique.

Daisuke Nakajima¹, Akihiro Ohsumi¹, Masatsugu Hamaji¹

¹Department of Thoracic Surgery, Kyoto University, 54 Shogoin-kawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan.

General Thoracic and Cardiovascular Surgery

|January 16, 2020

Summary

Lung autotransplantation with ex vivo bench surgery is a feasible technique for treating diverse lung diseases, demonstrating positive early outcomes. This approach offers an alternative to pneumonectomy for complex respiratory conditions.

Keywords:

Ex vivo surgery Lung autotransplantation Lung cancer Pneumonectomy

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Area of Science:

Thoracic Surgery
Transplantation Medicine
Surgical Oncology

Background:

Lung autotransplantation was initially developed to manage centrally located lung cancer, aiming to prevent pneumonectomy.
This case series explores the application of lung autotransplantation for a broader spectrum of lung diseases.

Observation:

A single-center case series involved five patients undergoing lung autotransplantation with ex vivo bench surgery between September 2014 and October 2018.
The surgical technique involved pneumonectomy, followed by ex vivo lobe separation, cold solution flushing, and reimplantation.

Findings:

Indications included postpneumonectomy-like syndrome, advanced lung cancer, pulmonary artery sarcoma, central lung cancer, and bronchopleural fistula.
One patient experienced mild bronchial anastomosis stenosis requiring intervention; another died from sarcoma recurrence.
The remaining patients survived with no disease recurrence and no significant post-transplant complications.

Implications:

Lung autotransplantation with ex vivo bench surgery is technically feasible for various challenging lung pathologies.
The procedure shows a favorable early post-transplant outcome, offering a viable alternative for patients with complex lung diseases.
This approach expands the therapeutic options beyond traditional surgical methods for lung conditions.