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The Anaphase Promoting Complex/Cyclosome (APC/C): A Versatile E3 Ubiquitin Ligase

Natalie L Curtis1, Victor M Bolanos-Garcia2

  • 1Faculty of Health and Life Sciences, Department of Biological and Medical Sciences, Oxford Brookes University, Oxford, OX3 0BP, England, UK.

Sub-Cellular Biochemistry
|January 16, 2020
PubMed
Summary

The Anaphase Promoting Complex/Cyclosome (APC/C) is crucial for cell division and has emerging roles in genomic integrity and nervous system development. APC/C dysregulation is implicated in Alzheimer's disease and cancer, making it a potential therapeutic target.

Keywords:
Anaphase Promoting Complex/Cyclosome (APC/C)Chromosome segregationE3 ubiquitin ligaseGenome instabilityKinetochoreMitosis regulationProteasomeSpindle Assembly Checkpoint (SAC)

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