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Updated: Dec 30, 2025

High-throughput Crystallization of Membrane Proteins Using the Lipidic Bicelle Method
Published on: January 9, 2012
The Effect of the Phospholipid Bilayer Environment on Cholesterol Crystal Polymorphism
Neta Varsano1, Fabio Beghi2, Tali Dadosh3
1Department of Structural Biology, Weizmann Institute of Science, 234 Herzl Street, Rehovot, 76100, Israel.
Abstract:
Invited for this month's cover are the group of Prof. Lia Addadi at the Weizmann Institute of Science, Israel and collaborators at the Università Degli Studi di Milano, Italy, and the ALBA Synchrotron Light Source, Spain. The front cover shows how cholesterol crystals form in macrophage cells and in lipid bilayers of different compositions. Cholesterol monohydrate stable triclinic crystals form in vitro as rhomb-shaped plates, whereas the monoclinic crystals fold into tubular or helical shapes. Read the full text of the article at 10.1002/cplu.201800632.
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