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Updated: Dec 30, 2025

A Scalable Balz-Schiemann Reaction Protocol in a Continuous Flow Reactor
Published on: February 10, 2023
Scalable Synthesis of Functionalized Ferrocenyl Azides and Amines Enabled by Flow Chemistry
Merlin Kleoff1, Johannes Schwan1, Lisa Boeser1
1Institut für Chemie und Biochemie , Organische Chemie, Freie Universität Berlin , Takustr. 3 , 14195 Berlin , Germany.
Abstract:
A scalable access to functionalized ferrocenyl azides has been realized in flow. By halogen-lithium exchange of ferrocenyl halides and trapping with tosyl azide, a variety of functionalized ferrocenyl azides were obtained in high yields. To allow a scalable preparation of these potentially explosive compounds, a flow protocol was developed accelerating the reaction time to minutes and circumventing accumulation of potentially hazardous intermediates. The corresponding ferrocenyl amines were then prepared by a reliable reduction process.
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