Frequent plateletpheresis donations & its effect on haematological parameters: An observational study

Area of Science:

• Transfusion Medicine
• Hematology

Background:

• Donor well-being during frequent plateletpheresis is a significant concern.
• Understanding the impact on haematological parameters (HP) is crucial for repeat donors.

Purpose of the Study:

• To analyze the effect of frequent plateletpheresis on the haematological parameters of repeat donors.
• To assess donor safety and well-being in the context of repeated donations.

Main Methods:

• Study involved repeat plateletpheresis donors undergoing 2nd, 3rd, and 4th donations within a specific timeframe.
• Haematological parameters (HP) were monitored at follow-up after donations.
• Data from three different cell separators were compared.

Main Results:

• No significant alterations in most HPs were observed in 98 donors, except for mean platelet volume (P <0.05).
• Follow-up within a week versus 8-30 days showed no significant HP changes, barring platelet count variation (P=0.025).
• Donors undergoing 3rd and 4th donations showed minimal HP differences, with similar outcomes across three cell separators.

Conclusions:

• Frequent plateletpheresis can be safely performed without adverse effects on donor haematological parameters.
• Donor well-being is not compromised by repeated platelet donation procedures.
• Different cell separators used for plateletpheresis demonstrate comparable safety profiles regarding post-donation haematological parameters.