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Acromegaly in the elderly patient.

Raquel S Jallad¹, Marcello D Bronstein¹

¹Unidade de Neuroendocrinologia, Serviço de Endocrinologia e Metabologia, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brasil.

Archives of Endocrinology and Metabolism

|January 16, 2020

Summary

This summary is machine-generated.

Acromegaly is increasingly diagnosed in the elderly, presenting diagnostic challenges due to aging similarities. Early diagnosis and treatment are crucial for better prognosis in older adults with this growth hormone disorder.

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Area of Science:

Endocrinology
Geriatric Medicine
Oncology

Background:

Acromegaly, caused by growth hormone hypersecretion, typically affects adults aged 30-40.
Recent data indicate a rising incidence and prevalence in the elderly population, linked to increased life expectancy.
Delayed diagnosis in older adults is common due to overlapping symptoms with natural aging processes.

Purpose of the Study:

To review the diagnosis, comorbidities, treatment, and prognosis of acromegaly in elderly patients.
To highlight the diagnostic challenges and management considerations specific to older individuals with acromegaly.

Main Methods:

Literature review focusing on acromegaly in the elderly population.
Analysis of diagnostic criteria, treatment options, and prognostic factors.

Main Results:

Elderly acromegaly patients exhibit a higher prevalence of comorbidities compared to younger individuals.
Diagnostic delays are frequent in the elderly, exacerbated by symptom overlap with aging.
Surgical adenoma removal is the primary treatment, with somatostatin receptor ligands effective as primary or adjuvant therapy.

Conclusions:

Acromegaly diagnosis and management in the elderly require careful consideration of age-related factors and comorbidities.
Prognosis is inversely related to patient age, disease duration, and final growth hormone levels.
Timely diagnosis and appropriate treatment are essential for improving outcomes in older acromegaly patients.