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Exploring Dysregulated Signaling Pathways in Cancer

Sabah Nisar1, Sheema Hashem1, Muzafar A Macha2,3

  • 1Translational Medicine, Research Branch, Sidra Medicine, Doha, Qatar.

Current Pharmaceutical Design
|January 16, 2020
PubMed

Insights

Cancer cell biology involves understanding disrupted signaling pathways. This review explores how these pathways contribute to tumor development and potential targeted therapies.

Area of Science:

  • Oncology
  • Cell Biology
  • Molecular Biology

Background:

  • Cellular signaling pathways regulate essential cell functions.
  • Disruption of these pathways is a hallmark of cancer.
  • Understanding these alterations is key to cancer research.

Purpose of the Study:

  • To review various signaling pathways involved in cancer.
  • To elucidate how their dysregulation contributes to tumor formation.
  • To highlight their potential as therapeutic targets.

Main Methods:

  • Literature review of signaling pathways in cancer.
  • Analysis of oncogenic mutations and abnormal gene expression.
  • Discussion of pathway dysregulation in tumor pathophysiology.

Main Results:

  • Identified key signaling pathways frequently altered in cancer.
  • Detailed how pathway disruptions promote uncontrolled cell growth and survival.
  • Linked pathway abnormalities to cancer invasion and metastasis.

Conclusions:

  • Dysregulated signaling pathways are critical drivers of cancer.
  • Targeting these specific pathways offers promising therapeutic strategies.
  • Further research into cancer cell signaling can improve treatments.
Keywords:
Angiogenesisapoptosiscell invasioncell proliferationdrug targetsmetastasissignaling pathwaystumor microenvironment.

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