Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

7.1K
Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
7.1K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

4.5K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
4.5K
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

6.8K
Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
6.8K
Notch Signaling Pathway03:14

Notch Signaling Pathway

6.3K
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
6.3K
The Intrinsic Apoptotic Pathway01:31

The Intrinsic Apoptotic Pathway

8.1K
Internal cellular stress, such as cellular injury or hypoxia, triggers intrinsic apoptosis. The B-cell lymphoma 2 (Bcl-2) family of proteins are the primary regulators of the intrinsic apoptotic pathway. For example, during DNA damage, checkpoint proteins, such as Ataxia Telangiectasia Mutated (ATM protein) and Checkpoints Factor-2 (Chk2) proteins, are activated. These proteins phosphorylate p53 which further activates pro-apoptotic proteins, such as Bax, Bak, PUMA, and Noxa, and inhibits...
8.1K
Autocrine Signaling01:01

Autocrine Signaling

51.7K
Autocrine signaling is one of the many signaling mechanisms that function inside multicellular organisms to carry out intercellular communication. In this type of signaling mechanism, the same cell that secretes an extracellular signaling molecule also expresses the receptors to bind and respond to that signaling molecule.
Autocrine Signaling in Macrophages
Under normal physiological conditions, autocrine signaling is essential for maintaining homeostasis. This process is well characterized in...
51.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pristimerin Suppresses Janus Kinase/Signal Transducers and Activators of Transcription Oncogenic Signaling To Drive Mitochondrial and Caspase-Dependent Apoptosis in Multiple Myeloma.

ACS pharmacology & translational science·2026
Same author

Metronomic Chemotherapy in Ovarian Cancer: Current Scenario and AI-Integrated Future Strategies.

Cancer reports (Hoboken, N.J.)·2026
Same author

Scalable risk stratification of undiagnosed heart failure using routine health data and its association with imaging phenotypes and outcomes.

Scientific reports·2026
Same author

Regulated cell death plasticity in cancer: thresholds, reversibility, and therapeutic failure.

Journal of translational medicine·2026
Same author

The power of phytochemicals in cancer chemoprevention through multi-target modulation of oncogenic signaling pathways.

Discover oncology·2026
Same author

Microdialysis-based metabolomic and proteomic profiling reveals signature variations for disease severity in psoriasis.

The Journal of investigative dermatology·2026

Related Experiment Video

Updated: Dec 30, 2025

Intracellular Phosphoflow Cytometry of Acute Myeloid Leukemia Patient-Derived Xenotransplants
07:38

Intracellular Phosphoflow Cytometry of Acute Myeloid Leukemia Patient-Derived Xenotransplants

Published on: June 6, 2025

572

Exploring Dysregulated Signaling Pathways in Cancer.

Sabah Nisar1, Sheema Hashem1, Muzafar A Macha2,3

  • 1Translational Medicine, Research Branch, Sidra Medicine, Doha, Qatar.

Current Pharmaceutical Design
|January 16, 2020
PubMed
Summary

Cancer cell biology involves understanding disrupted signaling pathways. This review explores how these pathways contribute to tumor development and potential targeted therapies.

Keywords:
Angiogenesisapoptosiscell invasioncell proliferationdrug targetsmetastasissignaling pathwaystumor microenvironment.

More Related Videos

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
10:21

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma

Published on: September 20, 2024

688
Author Spotlight: Exploring Salidroside's Molecular Mechanisms in Breast Cancer Treatment
11:13

Author Spotlight: Exploring Salidroside's Molecular Mechanisms in Breast Cancer Treatment

Published on: June 9, 2023

2.2K

Related Experiment Videos

Last Updated: Dec 30, 2025

Intracellular Phosphoflow Cytometry of Acute Myeloid Leukemia Patient-Derived Xenotransplants
07:38

Intracellular Phosphoflow Cytometry of Acute Myeloid Leukemia Patient-Derived Xenotransplants

Published on: June 6, 2025

572
Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
10:21

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma

Published on: September 20, 2024

688
Author Spotlight: Exploring Salidroside's Molecular Mechanisms in Breast Cancer Treatment
11:13

Author Spotlight: Exploring Salidroside's Molecular Mechanisms in Breast Cancer Treatment

Published on: June 9, 2023

2.2K

Area of Science:

  • Oncology
  • Cell Biology
  • Molecular Biology

Background:

  • Cellular signaling pathways regulate essential cell functions.
  • Disruption of these pathways is a hallmark of cancer.
  • Understanding these alterations is key to cancer research.

Purpose of the Study:

  • To review various signaling pathways involved in cancer.
  • To elucidate how their dysregulation contributes to tumor formation.
  • To highlight their potential as therapeutic targets.

Main Methods:

  • Literature review of signaling pathways in cancer.
  • Analysis of oncogenic mutations and abnormal gene expression.
  • Discussion of pathway dysregulation in tumor pathophysiology.

Main Results:

  • Identified key signaling pathways frequently altered in cancer.
  • Detailed how pathway disruptions promote uncontrolled cell growth and survival.
  • Linked pathway abnormalities to cancer invasion and metastasis.

Conclusions:

  • Dysregulated signaling pathways are critical drivers of cancer.
  • Targeting these specific pathways offers promising therapeutic strategies.
  • Further research into cancer cell signaling can improve treatments.