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Emerging Role of Angiotensin AT2 Receptor in Anti-Inflammation: An Update

Sanket N Patel1, Naureen Fatima1, Riyasat Ali1

  • 1Department of Pharmacological & Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX 77204, United States.

Current Pharmaceutical Design
|January 16, 2020
PubMed

Insights

The angiotensin II type 2 receptor (AT2R) shows anti-inflammatory effects by releasing cytokines and promoting tissue repair. Further research is needed to explore AT2R as a potential therapeutic target for inflammatory conditions.

Area of Science:

  • Immunology
  • Cardiovascular Research
  • Pharmacology

Background:

  • The Renin-Angiotensin System (RAS) plays a key role in inflammation, with the angiotensin II/AT1 receptor (AT1R) axis extensively studied.
  • The role of the angiotensin II type 2 receptor (AT2R) in inflammation is an emerging area of significant research interest.

Purpose of the Study:

  • To elucidate the emerging role of AT2R in modulating inflammatory responses.
  • To explore the potential of AT2R as a therapeutic target.

Main Methods:

  • Review of existing literature on AT2R expression and function in immune and non-immune cells.
  • Analysis of signaling pathways downstream of AT2R activation, including nitric oxide formation and phosphatase activity.

Main Results:

  • AT2R is expressed on various cell types and its activation triggers cytokine release.
  • AT2R activation demonstrates anti-inflammatory effects and prevents maladaptive tissue repair.
  • Signaling pathways involving nitric oxide and phosphatases are linked to AT2R's anti-inflammatory outcomes.

Conclusions:

  • AT2R activation promotes cell survival and tissue function through anti-inflammatory mechanisms.
  • The findings highlight the potential of AT2R as a novel therapeutic target for inflammatory diseases.
  • Further investigation into AT2R's therapeutic potential is warranted.
Keywords:
Angiotensin-II type 2 receptorimmune and non-immune cellsinflammationmaladaptive repairnitric oxidepathological conditions.

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