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Updated: Dec 30, 2025

Generation and 3-Dimensional Quantitation of Arterial Lesions in Mice Using Optical Projection Tomography
Published on: May 26, 2015
Effect of Ultra High-Resolution Computed Tomography and Model-Based Iterative Reconstruction on Detectability of
Hiroyuki Morisaka1, Yuta Shimizu2, Takuya Adachi2
1From the Diagnostic Radiology, Saitama Medical University International Medical Center, Saitama, Japan.
Objective:
To evaluate the effect of ultra high-resolution computed tomography (UHRCT) and model-based iterative reconstruction (MBIR) on the detectability of simulated submillimeter artery.
Methods:
A small vessel phantom ranging from 0.4 to 2.0 mm in diameter and edge phantoms of low to high attenuation values were scanned by UHRCT (super-high-resolution mode and normal-resolution-mode) and conventional CT, and data were reconstructed by MBIR and filtered back projection (FBP). Vessel detectability was assessed subjectively and the effective size at which 50% of response was achieved (ES50 [mm]) was calculated. Modulation transfer function (MTF) was calculated by an edge spread function method.
Results:
ES50 of super high-resolution mode (0.36 mm for MBIR and 0.50 mm for FBP) was significantly smaller than those of normal-resolution mode (P < 0.01). In the MTF analysis, the MTF of MBIR improved as the edge phantom attenuation increased, whereas that of FBP was stable.
Conclusions:
Both UHRCT and MBIR are effective for the detectability of simulated submillimeter artery.
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