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Updated: Dec 30, 2025

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Polypropylene mesh for hernia repair with controllable cell adhesion/de-adhesion properties.

Sonia Lanzalaco1, Luis Javier Del Valle1, Pau Turon2

  • 1Departament d'Enginyeria Química, EEBE, Universitat Politècnica de Catalunya, C/Eduard Maristany, 10-14, Ed. I.2, Barcelona, 08019, Spain. sonia.lanzalaco@upc.edu elaine.armelin@upc.edu and Barcelona Research Center for Multiscale Science and Engineering, Universitat Politècnica de Catalunya, C/Eduard Maristany, 10-14, Ed. I.S, Barcelona, 08019, Spain.

Journal of Materials Chemistry. B
|January 16, 2020
PubMed
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Researchers developed a novel polypropylene mesh with a thermosensitive hydrogel coating. This anti-adherent mesh significantly reduces fibroblast cell adhesion, offering a promising solution for abdominal hernia repair.

Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Polymer Chemistry

Background:

  • Abdominal hernia repair often involves surgical meshes that can cause unwanted tissue adhesion.
  • Developing anti-adherent materials is crucial for improving patient outcomes and reducing complications.

Purpose of the Study:

  • To create a versatile bilayer system combining a polypropylene (PP) mesh with a poly(N-isopropylacrylamide) (PNIPAAm) hydrogel.
  • To modulate cell adhesion properties by controlling hydrogel architecture and environmental temperature.
  • To investigate the potential of this system as an anti-adherent mesh for abdominal hernia repair.

Main Methods:

  • Fabrication of a polypropylene mesh coated with a covalently bonded PNIPAAm hydrogel.
  • Tuning hydrogel architecture via PNIPAAm grafting time, crosslinker concentration (N,N'-methylene bis(acrylamide) - MBA), and temperature relative to the Lower Critical Solution Temperature (LCST).

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  • Evaluation of cell adhesion (fibroblast COS-1, epithelial MCF-7) and material stability using in vitro assays and cold plasma treatment.

    • Main Results:

    • A porous iPP-g-PNIPAAm bilayer system, prepared with 2h PNIPAAm grafting and 1 mM MBA, showed optimal results.
    • Fibroblast cell detachment was 50% lower compared to control after 7 days, indicating significant anti-adhesion properties.
    • The bilayer system demonstrated excellent stability in both dry and wet conditions, confirming robust hydrogel adhesion to the plasma-activated PP surface.

    Conclusions:

    • The developed thermosensitive hydrogel-coated polypropylene mesh effectively reduces fibroblast cell adhesion.
    • This anti-adherent mesh system shows significant promise for improving abdominal hernia repair procedures.
    • Controlling hydrogel parameters and utilizing cold plasma activation are key to achieving desired anti-adhesion performance.