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Related Experiment Videos

Prophylaxis in appendicectomy with cefoxitin or ceftriaxone.

S D Lang1, A J Morris, P M Charlesworth

  • 1Department of Microbiology, Middlemore Hospital, Otahuhu, Auckland.

The New Zealand Medical Journal
|November 23, 1988
PubMed
Summary

Cefoxitin and ceftriaxone are equally effective for preventing infections during appendectomy surgery. This randomized trial found no significant difference in infection rates between the two antibiotics in patients undergoing appendicectomy.

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Area of Science:

  • Infectious Diseases
  • Surgical Prophylaxis
  • Clinical Pharmacology

Background:

  • Appendicectomy is a common surgical procedure.
  • Antibiotic prophylaxis is standard practice to prevent surgical site infections.
  • Choosing the optimal prophylactic antibiotic is crucial for patient outcomes.

Purpose of the Study:

  • To compare the efficacy and safety of cefoxitin versus ceftriaxone as prophylactic antibiotics in patients undergoing appendicectomy.
  • To evaluate the incidence of wound, urinary, and lower respiratory tract infections post-appendicectomy.

Main Methods:

  • Randomized controlled trial involving 240 adult patients undergoing acute appendicectomy.
  • Patients received either cefoxitin or ceftriaxone (1g IV) at anesthesia induction.

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  • Postoperative monitoring included daily assessments and a 4-week follow-up for infection evidence.

    • Main Results:

    • 167 patients were evaluated at follow-up; no significant difference in overall infection rates between cefoxitin and ceftriaxone groups.
    • Infection rates varied by appendix condition but showed no significant difference between antibiotics.
    • No serious infections were reported, and neither antibiotic caused adverse effects.

    Conclusions:

    • Both cefoxitin and ceftriaxone are effective and safe prophylactic antibiotics for appendicectomy.
    • The choice between cefoxitin and ceftriaxone may not significantly impact infection rates in this patient population.
    • Further research could explore cost-effectiveness or specific patient subgroups.