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Genetically Engineered Pigs to Study Cancer.

Daniela Kalla1, Alexander Kind1, Angelika Schnieke1

  • 1Chair of Livestock Biotechnology, School of Life Sciences, Technische Universität München, 85354 Freising, Germany.

International Journal of Molecular Sciences
|January 17, 2020
PubMed
Summary

Genetically engineered pigs offer a valuable non-rodent model for cancer research, bridging the gap between basic science and clinical applications for human cancer. This approach aids in developing new diagnostic and therapeutic strategies.

Keywords:
breast cancercolorectal cancergenome editingosteosarcomapancreatic cancerpigpreclinical cancer modelsswinetransgenic

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Area of Science:

  • Comparative oncology
  • Translational biomedical research
  • Genetically engineered animal models

Background:

  • Mice models have advanced cancer research but have limitations for clinical translation.
  • Non-rodent species are needed to complement existing cancer research models.
  • Pigs share significant physiological and anatomical similarities with humans, making them suitable for translational studies.

Purpose of the Study:

  • To review the technology for generating genetically modified pigs.
  • To provide an overview of existing porcine cancer models.
  • To discuss the future development of pig models in oncology.

Main Methods:

  • Review of genetic engineering technologies applicable to pigs.
  • Compilation and analysis of current porcine cancer models.
  • Discussion of the translational potential of these models.

Main Results:

  • Genetically modified pigs can effectively mimic key aspects of human cancers.
  • Porcine models offer advantages in size, physiology, and anatomy for translational research.
  • Replication of oncogenic mutations in pigs shows promise for studying cancer mechanisms.

Conclusions:

  • Genetically engineered pigs represent a powerful, complementary model for human cancer research.
  • The field of porcine oncology is emerging with significant potential for developing novel diagnostics and therapeutics.
  • Further development of pig cancer models will accelerate the translation of basic research to clinical practice.