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Smartphone Biosensor System with Multi-Testing Unit Based on Localized Surface Plasmon Resonance Integrated with

Zhiyuan Fan1,2, Zhaoxin Geng1,3, Weihao Fang1,2

  • 1State Key Laboratory of Integrated Optoelectronics, Institute of Semiconductors, Chinese Academy of Sciences, Beijing 100083, China.

Sensors (Basel, Switzerland)
|January 17, 2020
PubMed
Summary

A novel smartphone biosensor system (SBSM) enables simultaneous detection of multiple biomarkers for improved point-of-care testing (POCT). This portable device offers reliable and convenient multi-biomarker analysis, aiding in accurate patient diagnosis and monitoring.

Keywords:
localized surface plasmon resonancemicrofluidicsmultipoint biosensorpoint-of-careprotein detectionsmartphone

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Analytical Chemistry

Background:

  • Accurate diagnosis and monitoring of patient stages rely on detecting multiple biomarkers.
  • Current methods for multi-biomarker detection often lack the efficiency and portability required for point-of-care testing (POCT).

Purpose of the Study:

  • To develop a smartphone biosensor system with a multi-testing unit (SBSM) for simultaneous, POCT of multiple biomarkers.
  • To evaluate the performance and reliability of the SBSM compared to established methods like ELISA.

Main Methods:

  • Integration of localized surface plasmon resonance (LSPR) with multi-channel microfluidics in a smartphone-based system.
  • Design and assembly of modularized attachments including light source, optics, and smartphone integration.
  • Testing of clinical serum specimens for biomarkers CA125 and CA15-3 using the SBSM.

Main Results:

  • The SBSM demonstrated simultaneous detection of multiple biomarkers with high sensitivity (161.0 nm/RIU) and low limits of detection (LoD) for CA125 (4.2 U/mL) and CA15-3 (0.87 U/mL).
  • Results from the SBSM showed strong correlation and reliability when compared to enzyme-linked immunosorbent assays (ELISA).
  • The system proved convenient to operate, requiring minimal professional expertise.

Conclusions:

  • The SBSM is a viable and useful tool for multi-biomarker detection at the point-of-care.
  • Its compact size, multi-testing capability, user-friendliness, and customizable design make it suitable for widespread clinical application.
  • The SBSM facilitates efficient and accurate diagnosis and monitoring of patients through accessible biomarker analysis.