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Micro- to macro-phase separation transition in sequence-defined coacervates.

Charles E Sing1

  • 1Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, 600 S. Mathews Ave., Urbana, Illinois 61801, USA.

The Journal of Chemical Physics
|January 17, 2020
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Summary
This summary is machine-generated.

Complex coacervation drives phase separation in polymers. New theory shows sequence-defined polymers can tune this separation, transitioning from macro- to microphase separation with increased blockiness.

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Area of Science:

  • Polymer Science
  • Physical Chemistry
  • Materials Science

Background:

  • Complex coacervation, driven by oppositely charged polyelectrolytes, leads to phase separation.
  • This separation can be macrophase (homopolyelectrolytes) or microphase (block copolyelectrolytes).
  • Sequence-defined copolymers can also exhibit macrophase separation, with block length influencing the transition to microphase separation.

Purpose of the Study:

  • To incorporate sequence-defined coacervation theory into self-consistent field theory.
  • To investigate the impact of sequence-defined polyelectrolytes on phase separation.
  • To study sequence-defined polymers in inhomogeneous systems.

Main Methods:

  • Development of a theoretical framework integrating sequence-defined coacervation with self-consistent field theory.
  • Simulation and analysis of sequence-defined polyelectrolytes in solution.
  • Examination of the effects of sequence blockiness, block number, and salt concentration.

Main Results:

  • Blocky sequences significantly influence electrostatically driven macrophase separation.
  • A transition from macrophase to microphase separation is observed as sequence blockiness increases.
  • This transition is dependent on sequence blockiness, the number of blocks, and salt concentration.

Conclusions:

  • Self-consistent field theory can model sequence-defined polyelectrolyte behavior.
  • Sequence architecture is a critical factor in controlling complex coacervation and phase separation.
  • The findings provide a theoretical basis for designing polymers with tunable phase separation properties.