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Adverse effects of cannabinoids.

Carla Anciones1, Antonio Gil-Nagel1

  • 1Epilepsy Program, Neurology Department, Hospital Ruber Internacional, Madrid, Spain.

Epileptic Disorders : International Epilepsy Journal with Videotape
|January 17, 2020
PubMed
Summary

Cannabidiol (CBD) is approved for specific epilepsies, generally well-tolerated short-term. However, severe reactions can occur, especially when combined with other seizure medications.

Keywords:
EpidiolexEpidyolexadverse reactionscannabidiolclinical trialsside effects

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Area of Science:

  • Pharmacology
  • Neurology
  • Clinical Medicine

Background:

  • Cannabidiol (CBD) is a cannabinoid product approved for treating drug-resistant seizures in epileptic encephalopathies.
  • Conditions include Dravet Syndrome and Lennox-Gastaut Syndrome.

Purpose of the Study:

  • To review the short-term adverse events associated with cannabidiol treatment.
  • To highlight potential severe reactions and drug interactions.

Main Methods:

  • Review of clinical trial data on cannabidiol's short-term side effects.
  • Analysis of adverse events, including those related to co-administered antiseizure drugs.

Main Results:

  • Short-term side effects are typically mild, dose-dependent, and transient (e.g., somnolence, decreased appetite, diarrhea).
  • Severe, life-threatening reactions are possible, often linked to interactions with other antiseizure drugs like sodium valproate or clobazam.

Conclusions:

  • Cannabidiol is generally well-tolerated in the short term for specific epilepsy types.
  • Careful monitoring is essential due to potential severe adverse events and drug interactions, necessitating further long-term safety studies.