Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations01:19

Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations

301
The pathophysiology of Acute Coronary Syndrome [ACD] involves several key processes:The main underlying cause of ACD is atherosclerosis, a chronic inflammatory disease characterized by the buildup of lipid-laden plaques within the coronary arteries.As the atherosclerotic plaque grows in the coronary artery, it may become unstable due to the formation of a lipid-rich core and a thin fibrous cap. Inflammatory cells within the plaque, such as macrophages, secrete enzymes that degrade the...
301
Acute Coronary Syndrome I: Introduction01:30

Acute Coronary Syndrome I: Introduction

626
Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...
626
Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

309
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
309
Aneurysm II: Clinical Manifestations and Diagnostic Studies01:21

Aneurysm II: Clinical Manifestations and Diagnostic Studies

154
Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
154

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Strengthening care and research in ALS in Southeast Asia: a call for action.

Amyotrophic lateral sclerosis & frontotemporal degeneration·2026
Same author

Longitudinal assessment of cortical motor function in amyotrophic lateral sclerosis.

Scientific reports·2025
Same author

Neurotoxic risks from over-the-counter vitamin supplements.

The Medical journal of Australia·2023
Same author

Idiopathic CD4 lymphopenia in a case of disseminated cryptococcosis with brain, vertebral spine and reproductive organ involvement.

Clinical medicine (London, England)·2019

Related Experiment Video

Updated: Dec 30, 2025

Portable Thermographic Screening for Detection of Acute Wallenberg's Syndrome
05:12

Portable Thermographic Screening for Detection of Acute Wallenberg's Syndrome

Published on: September 19, 2019

6.9K

Neurosyphilis presenting as acute ischemic stroke.

Dhayalen Krishnan1, Siti Sm Zaini2, Kartikasalwah A Latif2

  • 1Kuala Lumpur General Hospital, Kuala Lumpur, Malaysia kdhayalen@yahoo.com.

Clinical Medicine (London, England)
|January 17, 2020
PubMed
Summary

Neurosyphilis, a central nervous system infection, is increasing, particularly with HIV. Early diagnosis and penicillin treatment are crucial for recovery from this

Keywords:
MRIMeningovascular syphilisarteritisstroke

More Related Videos

Pre-Chiasmatic, Single Injection of Autologous Blood to Induce Experimental Subarachnoid Hemorrhage in a Rat Model
09:14

Pre-Chiasmatic, Single Injection of Autologous Blood to Induce Experimental Subarachnoid Hemorrhage in a Rat Model

Published on: June 18, 2021

2.6K
Isolation and Flow Cytometric Assessment of Neuroimmune Interactions in a Mini-Stroke Murine Model
08:22

Isolation and Flow Cytometric Assessment of Neuroimmune Interactions in a Mini-Stroke Murine Model

Published on: June 20, 2025

369

Related Experiment Videos

Last Updated: Dec 30, 2025

Portable Thermographic Screening for Detection of Acute Wallenberg's Syndrome
05:12

Portable Thermographic Screening for Detection of Acute Wallenberg's Syndrome

Published on: September 19, 2019

6.9K
Pre-Chiasmatic, Single Injection of Autologous Blood to Induce Experimental Subarachnoid Hemorrhage in a Rat Model
09:14

Pre-Chiasmatic, Single Injection of Autologous Blood to Induce Experimental Subarachnoid Hemorrhage in a Rat Model

Published on: June 18, 2021

2.6K
Isolation and Flow Cytometric Assessment of Neuroimmune Interactions in a Mini-Stroke Murine Model
08:22

Isolation and Flow Cytometric Assessment of Neuroimmune Interactions in a Mini-Stroke Murine Model

Published on: June 20, 2025

369

Area of Science:

  • Neurology
  • Infectious Diseases
  • Neuroscience

Background:

  • Neurosyphilis, caused by *Treponema pallidum*, is a central nervous system infection.
  • Historically prevalent, its incidence declined with penicillin but is now rising, especially with HIV coinfection.
  • It stems from untreated primary syphilis and presents with diverse neurological manifestations.

Observation:

  • The 'great imitator' often presents with neuropsychiatric disorders, mimicking other conditions.
  • A case study highlights a 39-year-old man with stroke-like symptoms (aphasia, facial weakness).
  • Initial CT scan suggested a stroke, but further investigation confirmed neurosyphilis.

Findings:

  • Neurosyphilis can mimic cerebrovascular accidents, leading to diagnostic challenges.
  • Prompt diagnosis is vital due to its potential for severe neurological damage.
  • The patient received intravenous benzylpenicillin, leading to a successful recovery.

Implications:

  • Increased vigilance and high index of suspicion are necessary for diagnosing neurosyphilis.
  • Understanding its varied presentations is key to avoiding misdiagnosis.
  • Effective treatment with penicillin can lead to significant patient recovery.