Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Role of Hippocampus in Memory

Role of Hippocampus in Memory

The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Epigenetic Dynamics of Human Spermatogenesis and Their Dysregulation in Non-Obstructive Azoospermia.

Protein & cell·2026

Same author

Systematic Identification of Molecular Signatures Dictating Therapeutic Effects of Clinically First-Line Chemotherapy Regimens for Human Gastric Cancer Patients Based on Organoid Model.

MedComm·2026

Same author

Rising Star: Single Cell Omics Technologies: When Whole Omics Analysis Meets Single Cell Resolution.

Journal of molecular biology·2026

Same author

A targeted DNA methylation method for detecting gastrointestinal cancer in circulating cell-free DNA.

iScience·2026

Same author

Single-cell omics sequencing technologies: the long-read generation.

Trends in genetics : TIG·2025

Same author

Multi-omics analysis reveals single-cell meiotic hotspot dynamics and epigenomic regulations in female mammals.

Cell reports·2025

Same journal

Daily briefing: 'Cyborg' cockroaches breathe underwater with printed suit.

Nature·2026

Same journal

China boosts prestigious grants for young scientists - will it ease competition?

Nature·2026

Same journal

Incoming US science academy chief vows to 'double down' on research.

Nature·2026

Same journal

Author Correction: Synthesis of enantioenriched atropisomers by biocatalytic deracemization.

Nature·2026

Same journal

Electrodeposited self-assembled molecules for perovskite photovoltaics.

Nature·2026

Same journal

Neutrino's nursery found: the 'Shadow Blaster'.

Nature·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Dec 30, 2025

Longitudinal Two-Photon Imaging of Dorsal Hippocampal CA1 in Live Mice

Longitudinal Two-Photon Imaging of Dorsal Hippocampal CA1 in Live Mice

Published on: June 19, 2019

Decoding the development of the human hippocampus.

Suijuan Zhong¹, Wenyu Ding², Le Sun^1,3,4

¹State Key Laboratory of Brain and Cognitive Science, CAS Center for Excellence in Brain Science and Intelligence Technology, Institute of Brain-Intelligence Technology (Shanghai), Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.

|January 17, 2020

Summary

This summary is machine-generated.

This study maps human hippocampal development using single-cell sequencing, revealing 47 cell subtypes and their developmental paths. Findings offer insights into brain development and related diseases.

More Related Videos

Combined Mechanical and Enzymatic Dissociation of Mouse Brain Hippocampal Tissue

Combined Mechanical and Enzymatic Dissociation of Mouse Brain Hippocampal Tissue

Published on: October 21, 2021

Horizontal Hippocampal Slices of the Mouse Brain

Horizontal Hippocampal Slices of the Mouse Brain

Published on: September 22, 2020

Related Experiment Videos

Last Updated: Dec 30, 2025

Longitudinal Two-Photon Imaging of Dorsal Hippocampal CA1 in Live Mice

Longitudinal Two-Photon Imaging of Dorsal Hippocampal CA1 in Live Mice

Published on: June 19, 2019

Combined Mechanical and Enzymatic Dissociation of Mouse Brain Hippocampal Tissue

Combined Mechanical and Enzymatic Dissociation of Mouse Brain Hippocampal Tissue

Published on: October 21, 2021

Horizontal Hippocampal Slices of the Mouse Brain

Horizontal Hippocampal Slices of the Mouse Brain

Published on: September 22, 2020

Area of Science:

Neuroscience
Developmental Biology
Genomics

Background:

The hippocampus is crucial for memory and navigation.
Understanding human hippocampal development is vital for neuroscience and medicine.

Purpose of the Study:

To map cell types, lineages, molecular features, and transcriptional regulation in the developing human hippocampus.
To identify developmental trajectories and regional markers.

Main Methods:

Single-cell RNA sequencing and ATAC-seq analysis of 30,416 human hippocampal cells (gestational weeks 16-27).
Multiomic data integration to uncover transcriptional regulatory networks.
Comparative analysis with mouse models.

Main Results:

Identification of 47 distinct cell subtypes and their developmental trajectories.
Characterization of progenitor cell migration and lineage.
Discovery of regional markers for CA1, CA3, and dentate gyrus neurons.
Uncovered transcriptional regulatory networks, including PROX1.
Revealed species-specific gene expression patterns and the role of NBPF1.

Conclusions:

Provides a comprehensive blueprint of human hippocampal development.
Offers a tool for investigating hippocampal development and associated diseases.
Highlights conserved and divergent features between human and mouse hippocampal development.