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Odontogenic keratocyst with granular cell changes: A distinctive finding
Revati Shailesh Deshmukh1, Radhika M Bavle2, Priya Nimish Deo1
1Department of Oral and Maxillofacial Pathology and Oral Microbiology, Bharati Vidyapeeth Deemed to be University Dental College and Hospital, Pune, Maharashtra, India.
Journal of Oral and Maxillofacial Pathology : JOMFP
|January 17, 2020
Summary
Odontogenic keratocyst (OKC), an aggressive oral cyst, typically affects the mandible. This report details the first documented case of an OKC exhibiting granular cell changes in a young male patient.
Area of Science:
- Oral pathology
- Odontogenic cysts
- Histopathology
Background:
- Odontogenic keratocyst (OKC) arises from dental lamina, predominantly in the posterior mandible.
- OKC is characterized by aggressive behavior, rapid growth, and bone invasion.
- High recurrence rates are a significant clinical challenge for OKC management.
Observation:
- This study presents a rare case of OKC in a 27-year-old male.
- The observed OKC exhibited unusual granular cell changes.
- This represents the first reported instance of such histological variation in an OKC.
Findings:
- The OKC demonstrated distinct granular cell morphology.
- Calcifications, dentinoid formation, and ossification have been noted in previous OKC cases.
- This case adds granular cell changes to the spectrum of OKC histopathological variations.
Implications:
- Understanding diverse OKC histopathology aids in accurate diagnosis and treatment planning.
- Recognizing granular cell changes may influence prognostic assessments and management strategies for OKC.
- Further research into the origins and behavior of OKC variants is warranted.
