Related Experiment Video

Updated: Dec 30, 2025

Isolation of Endothelial Progenitor Cells from Healthy Volunteers and Their Migratory Potential Influenced by Serum Samples After Cardiac Surgery
08:43

Isolation of Endothelial Progenitor Cells from Healthy Volunteers and Their Migratory Potential Influenced by Serum Samples After Cardiac Surgery

Published on: February 14, 2017

11.4K

Endothelial progenitor cells in cardiovascular diseases

Yumin Qiu1, Chanjuan Zhang1, Gaoxing Zhang2

  • 1Department of Hypertension and Vascular Disease The First Affiliated Hospital Sun Yat-Sen University Guangzhou China.

Aging Medicine (Milton (N.S.W))
|January 17, 2020
PubMed

Insights

Endothelial progenitor cells (EPCs) aid in blood vessel repair and may treat cardiovascular diseases (CVDs). This review explores EPC characteristics, influencing factors, and their therapeutic potential for CVDs.

Area of Science:

  • Cardiovascular Research
  • Stem Cell Biology
  • Regenerative Medicine

Background:

  • Cardiovascular diseases (CVDs) represent a significant global health burden, being the primary cause of mortality worldwide.
  • Endothelial progenitor cells (EPCs), originating from hematopoietic stem cells, possess crucial angiogenic capabilities essential for vascular repair.
  • Existing research highlights a correlation between coronary heart disease and the levels of circulating EPCs.

Purpose of the Study:

  • To review the fundamental biological characteristics of endothelial progenitor cells (EPCs).
  • To examine factors that influence the quantity and functional capacity of EPCs.
  • To elucidate the role of EPCs in the therapeutic strategies for cardiovascular diseases.

Main Methods:

  • Literature review focusing on endothelial progenitor cells (EPCs).
  • Analysis of studies investigating EPCs in relation to cardiovascular disease (CVD).
  • Synthesis of information on EPC biology, influencing factors, and therapeutic applications.

Main Results:

  • EPCs exhibit key biological properties relevant to vascular health and repair.
  • Various intrinsic and extrinsic factors modulate EPC number and function.
  • EPCs demonstrate significant potential in the treatment and management of cardiovascular diseases.

Conclusions:

  • Understanding EPC biology is crucial for advancing cardiovascular therapies.
  • Modulating EPCs offers a promising avenue for regenerative medicine approaches to CVD.
  • Future research directions in EPC therapy hold potential for improved patient outcomes in cardiovascular medicine.

Keywords:
EPC therapycardiovascular diseasesendothelial dysfunctionendothelial progenitor cells

More Related Videos

Isolation of Endothelial Progenitor Cells from Human Umbilical Cord Blood07:26

Isolation of Endothelial Progenitor Cells from Human Umbilical Cord Blood

Published on: September 14, 2017

11.7K
Phenotypic and Functional Characterization of Endothelial Colony Forming Cells Derived from Human Umbilical Cord Blood13:46

Phenotypic and Functional Characterization of Endothelial Colony Forming Cells Derived from Human Umbilical Cord Blood

Published on: April 13, 2012

16.6K

Related Concept Videos

Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
3.3K
Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
3.7K
Production of Formed Elements01:34

Production of Formed Elements

Hemangioblasts are multipotent stem cells originating from the mesoderm. They give rise to hematopoietic stem cells (HSCs), which undergo hematopoiesis to produce all the formed elements of blood. This process is regulated by a complex network of hematopoietic growth factors, including transcription factors, growth factors, and cytokines. These factors stimulate the HSCs to divide and differentiate, though some HSCs remain undifferentiated to maintain a self-renewing pool.
Most HSCs commit to...
3.5K
Overview of the Vascular System01:20

Overview of the Vascular System

The vascular system comprises an extensive network of arteries, capillaries, and veins. The vascular system can be broadly divided into the blood and lymphatic systems. Typically, blood vessels can be categorized into three histological regions: tunica intima, tunica media, and tunica adventitia. The tunica intima consists of a single layer of endothelial cells attached to the basal lamina. Underlying the basal lamina is a connective tissue layer and an elastic lamina that gives stability and...
3.3K
Hematopoiesis01:21

Hematopoiesis

The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
8.3K
Mechanism of Angiogenesis01:10

Mechanism of Angiogenesis

Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...
6.5K