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Estimation of apolipoprotein A in early onset ST-segment elevation myocardial infarction
Ameen Mosa Mohammad1, Ahmed Hasan Yousif2, Bayar Ahmed Qasim1
1Department of Medicine, College of Medicine, University of Duhok.
Insights
Apolipoprotein A levels were not significantly lower in young heart attack patients, but were lower in males, smokers, and those with dyslipidemia. These risk factors are linked to early-onset myocardial infarction.
Area of Science:
- Cardiology
- Biochemistry
- Preventive Medicine
Background:
- The role of apolipoprotein A in early-onset ST-segment elevation myocardial infarction (STEMI) remains unclear.
- Understanding its association with cardiovascular risk factors is crucial for early intervention.
Purpose of the Study:
- To assess apolipoprotein A levels in patients with early-onset STEMI.
- To correlate apolipoprotein A levels with traditional cardiovascular risk factors in this cohort.
Main Methods:
- A case-control study involving 50 patients with early-onset STEMI (age < 50) and 40 healthy controls.
- Demographic, clinical characteristics, and cardiovascular risk factors were recorded.
- Apolipoprotein A levels were measured in all participants.
Main Results:
- Mean age of cases was 43.37 ± 5.85 years.
- Apolipoprotein A levels were not significantly different between cases and controls (P=0.52).
- Lower apolipoprotein A levels were observed in male patients, current smokers, and those with dyslipidemia (P<0.05).
- Linear regression showed significant associations between early-onset STEMI and male gender (P<0.001) and dyslipidemia (P=0.030).
Conclusions:
- Lower apolipoprotein A levels correlate with conventional risk factors in early-onset STEMI.
- Targeting apolipoprotein A may be beneficial in young patients with multiple cardiovascular risk factors.
- Further research is needed to establish apolipoprotein A's diagnostic and prognostic role in STEMI.
Aims:
The role of apolipoprotein A in early onset ST-segment elevation myocardial infarction is not clear. This study sought to assess the apolipoprotein A in cohort of patients diagnosed with early onset acute ST-segment elevation myocardial infarction and to corelate it with major traditional cardiovascular risk factors.
Methods:
A total of 50 such patients and 40 age and sex-matched healthy controls, both aged less than 50 years with their baseline demographic, clinical characteristics and cardiovascular risk factors were studied. Apolipoprotein A was estimated for all enrollees.
Results:
The mean age of cases was 43.37 ± 5.85 years. The levels of apolipoprotein A among cases were not significantly lower compared to controls (P = 0.52). They were lower among the male, current smokers and the dyslipidemia (P's < 0.05). Considering the apolipoprotein A as the dependent factor, the early onset ST-segment elevation myocardial infarction was associated significantly with the male and the dyslipidemia in linear regression (P < 0.001 and 0.030), respectively.
Conclusion:
Lower levels of apolipoprotein A are significantly related to conventional risk factors in early onset ST-segment elevation myocardial infarction. This apolipoprotein A that particularly develops in young patients with clustering of traditional cardiovascular risk factors should be targeted. Further studies are warranted to determine the diagnostic and prognostic indicators of this apolipoprotein in ST-segment elevation myocardial infarction.
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