Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Urinary Bladder01:23

Urinary Bladder

2.8K
The urinary bladder is a hollow, muscular sac that temporarily stores urine before it is expelled from the body. It can hold approximately 600 mL of urine prior to micturition. The bladder is retroperitoneal and located behind the pubic symphysis in the pelvic floor.
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...
2.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impact of Prior Holmium Laser Enucleation of the Prostate on Robot-Assisted Radical Prostatectomy Outcomes: A Systematic Review and Meta-Analysis of Comparative Studies.

Journal of endourology·2026
Same author

Six-month outcomes of a three-arm prospective study comparing Da Vinci vs. Hugo RAS vs. versius robotic radical prostatectomy: (the COMPAR-P trial).

Journal of robotic surgery·2026
Same author

Autologous Tissue Substitutes for Ureteral Reconstruction: A Systematic Review of Surgical Techniques and Outcomes.

European urology open science·2026
Same author

Prostate Cancer Index Density, the Ratio of Percentage of Biopsy-Positive Cores to Prostate Volume, and Predicted Lethal Disease in the EAU Intermediate Prognostic Risk Class: Analysis and Implications in 651 Consecutive Patients Treated with Robot-Assisted Radical Prostatectomy at a Tertiary Referral Centre.

Cancers·2026
Same author

Is the Barthel index a valid tool for patient selection before urological surgery? A systematic review.

The Canadian journal of urology·2025
Same author

Index Cancer Density Is a Stronger Predictor of Pelvic Lymph Node Invasion than Percentage of Biopsy-Positive Cores in EAU High-Risk Prostate Cancer: Clinical Impact in 254 Patients Treated and Staged with Robot-Assisted Radical Prostatectomy.

Cancers·2025

Related Experiment Video

Updated: Dec 30, 2025

An Orthotopic Bladder Cancer Model for Gene Delivery Studies
07:48

An Orthotopic Bladder Cancer Model for Gene Delivery Studies

Published on: December 1, 2013

13.0K

Bladder cancer genomics.

Salvatore Siracusano1, Riccardo Rizzetto1, Antonio Benito Porcaro1

  • 1Department of Urology, University of Verona, Verona, Italy.

Urologia
|January 17, 2020
PubMed
Summary

Molecular subtyping of bladder cancer, based on genetic alterations like FGFR3, TP53, and RB1, aids in personalized treatment. This classification helps identify patients who may not benefit from chemotherapy, improving bladder cancer management.

Keywords:
Bladder cancergeneticsimmunotherapymolecular pathologytargeted agents

More Related Videos

Culture of Bladder Cancer Organoids as Precision Medicine Tools
08:39

Culture of Bladder Cancer Organoids as Precision Medicine Tools

Published on: December 28, 2021

5.2K
Cell-Free DNA Integrity Analysis in Urine Samples
07:58

Cell-Free DNA Integrity Analysis in Urine Samples

Published on: January 5, 2017

14.2K

Related Experiment Videos

Last Updated: Dec 30, 2025

An Orthotopic Bladder Cancer Model for Gene Delivery Studies
07:48

An Orthotopic Bladder Cancer Model for Gene Delivery Studies

Published on: December 1, 2013

13.0K
Culture of Bladder Cancer Organoids as Precision Medicine Tools
08:39

Culture of Bladder Cancer Organoids as Precision Medicine Tools

Published on: December 28, 2021

5.2K
Cell-Free DNA Integrity Analysis in Urine Samples
07:58

Cell-Free DNA Integrity Analysis in Urine Samples

Published on: January 5, 2017

14.2K

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Traditional bladder cancer treatment relied on surgery, immunotherapy, or chemotherapy.
  • Recent advances in molecular analysis have revealed novel treatment strategies.
  • Understanding genetic alterations is crucial for classifying and treating bladder cancer.

Purpose of the Study:

  • To classify bladder cancers based on molecular alterations.
  • To differentiate between basal and luminal subtypes.
  • To correlate molecular subtypes with disease progression and treatment response.

Main Methods:

  • Utilizing polymerase chain reaction and genomic hybridization techniques.
  • Analyzing DNA alterations and gene expression patterns.
  • Leveraging data from projects like The Cancer Genome Atlas (TCGA).

Main Results:

  • Bladder cancers classified as papillary (FGFR3 mutations) or non-papillary (TP53, RB1 mutations).
  • Gene expression patterns identify basal (squamous, sarcomatoid) and luminal (papillary) subtypes.
  • Luminal cancers linked to muscle-invasive disease; basal cancers to advanced/metastatic disease.
  • Specific DNA mutations correlate with cisplatin chemotherapy sensitivity.

Conclusions:

  • Molecular subtyping of bladder cancer can guide personalized treatment strategies.
  • Classification may help identify chemoresistant tumors, allowing avoidance of neoadjuvant chemotherapy.
  • Targeting genomic alterations offers a promising therapeutic approach for invasive urothelial cancers.
  • Future research aims to combine treatment strategies based on genetic mutational load.