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Pregnancy associated breast cancer
1Hoag Hospital, Newport Beach, California.
The Breast Journal
|January 17, 2020
Summary
Pregnancy associated breast cancer (PABC) is diagnosed late. Treatments like surgery and chemotherapy are safe after the first trimester, but others are delayed until after delivery to protect the fetus.
Area of Science:
- Oncology
- Maternal-Fetal Medicine
Background:
- Pregnancy associated breast cancer (PABC) presents diagnostic challenges.
- Timely diagnosis and treatment are crucial for maternal and fetal outcomes.
Purpose of the Study:
- To review the diagnosis and management of PABC.
- To highlight treatment considerations based on gestational age and fetal safety.
Main Methods:
- Literature review of PABC diagnosis and treatment strategies.
- Analysis of treatment safety profiles concerning gestational age.
Main Results:
- Delayed diagnosis is a significant issue in PABC.
- Surgery and chemotherapy are feasible after the first trimester.
- Radiation, anti-HER2, and endocrine therapies are deferred until postpartum due to fetal risks.
- Iatrogenic prematurity is a likely cause of long-term fetal complications.
Conclusions:
- Multidisciplinary care is essential for PABC patients and families.
- Treatment timing must balance maternal oncologic needs with fetal well-being.
- Social support is critical for managing PABC.
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