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Novel N-Acyl-1H-imidazole-1-carbothioamides: Design, Synthesis, Biological and Computational Studies

Hamid Aziz1, Aamer Saeed1, Muhammad Aslam Khan2

  • 1Department of Chemistry, Quaid-I-Azam University, Islamabad, 45320, Pakistan.

Chemistry & Biodiversity
|January 17, 2020
PubMed

Keywords:
DNA transferantioxidantsbiological activityfree radicalmulti drug resistantreactive speciesthiourea

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The Hofmann and Curtius rearrangement reactions can be applied to synthesize primary amines from carboxylic acid derivatives such as amides and acyl azides. In the Hofmann rearrangement, a primary amide undergoes deprotonation in the presence of a base, followed by halogenation to generate an N-haloamide. A second proton abstraction produces a stabilized anionic species, which rearranges to an isocyanate intermediate via an alkyl group migration from the carbonyl carbon to the neighboring...
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The IUPAC and common names of amides are derived from the parent carboxylic acid, by replacing the suffix “oic acid” and “ic acid,” respectively, with “amide.” In the following example, the IUPAC name ethanamide is derived from ethanoic acid, and the common name, acetamide, is obtained from acetic acid.
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