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Preparation and Characterization of Nanoliposomes for the Entrapment of Bioactive Hydrophilic Globular Proteins
Published on: August 31, 2019
Recent Strategies in Resveratrol Delivery Systems
Noelia D Machado1,2, Mariana A Fernández1,2, David Díaz Díaz3,4
1Universidad Nacional de Córdoba Facultad de Ciencias Químicas Departamento de Química Orgánica, Ciudad Universitaria, X5000HUA, Cordoba, Argentina.
Abstract:
Resveratrol, a natural polyphenolic stilbenoid widely found in grapes and wines, displays beneficial properties such as cardio-protective, antioxidant and anti-inflammatory activities. Trans-resveratrol (RSV) is the most bioactive and more abundant stereoisomer found in nature. Despite the positive properties of RSV, there are various factors that limit its effectiveness, including low aqueous solubility, low oral bioavailability and chemical instability. During the last years, an increasing number of strategies such as nano and micro encapsulation have been developed in order to overcome these limitations and enhance the use of RSV in nutritional and pharmaceutical applications. This Review summarizes the advances and main properties of several RSV carriers and delivery systems reported during the last 5 years.
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