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Updated: Dec 30, 2025

Chemoselective Modification of Viral Surfaces via Bioorthogonal Click Chemistry
Published on: August 19, 2012
Multifunctional Clickable Reagents for Rapid Bioorthogonal Astatination and Radio-Crosslinking
Christoph Denk1, Martin Wilkovitsch1, Emma Aneheim2
1Institute of Applied Synthetic Chemistry, Vienna University of Technology (TU Wien), Getreidemarkt 9/163, 1060, Vienna, Austria.
Abstract:
Invited for this month's cover is the group of Dr. Hannes Mikula at Vienna University of Technology (TU Wien), Austria. The cover picture shows immobilized astatine-labeled reagents that have been sterically shielded with polyethylene chains by rapid bioorthogonal ligation leading to increased stability of the radiolabel in biological media. These multifunctional and bioorthogonal 211 At reagents can be efficiently prepared by rapid click assembly and simultaneous astatination. Read the full text of the article at 10.1002/cplu.201900114.
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