Antibody therapies for multiple myeloma
Ioannis Ntanasis-Stathopoulos1, Maria Gavriatopoulou1, Evangelos Terpos1
1Department of Clinical Therapeutics, Alexandra General Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Immunotherapy using monoclonal antibodies, including anti-CD38 and bispecific antibodies, offers a promising strategy for treating multiple myeloma (MM). These therapies activate immune cells to target and destroy cancer cells, improving patient outcomes.
Area of Science:
- Oncology
- Immunology
- Pharmacology
Background:
- Multiple myeloma (MM) involves uncontrolled plasma cell proliferation and immune system dysregulation.
- Immunotherapy presents a promising therapeutic avenue for MM treatment.
Purpose of the Study:
- To review current antibody-based immunotherapies for multiple myeloma.
- To discuss the efficacy and potential of monoclonal antibodies and bispecific antibodies in MM treatment.
Main Methods:
- Review of monoclonal antibodies targeting CD38 and B-cell maturation antigen.
- Analysis of bispecific antibodies engaging T-cells to myeloma cells.
Main Results:
- Anti-CD38 antibodies are integral to effective combination regimens for newly diagnosed and relapsed/refractory MM.
- Bispecific antibodies demonstrate promising results in heavily pre-treated MM patients.
Conclusions:
- Antibody therapy has significantly advanced MM treatment options.
- Future research should focus on personalized combination regimens to optimize efficacy and safety.
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