Related Experiment Video
Updated: Dec 30, 2025
08:09
Echocardiographic Assessment of Cardiac Anatomy and Function in Adult Rats
Published on: December 13, 2019
22.5K
Echocardiographic parameters differentiating heart failure with preserved ejection fraction from asymptomatic left
Ismail Mohamed Ibrahim1, Hesham Hafez1, Mohamad Hossam Aldin Al-Shair1
1Department of Cardiology, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Echocardiography (Mount Kisco, N.Y.)
|January 17, 2020
Summary
Reduced lateral e' velocity is a key indicator for symptomatic left ventricular diastolic dysfunction (LVDD). This finding helps differentiate between asymptomatic LVDD and heart failure with preserved ejection fraction (HFpEF).
Area of Science:
- Cardiology
- Echocardiography
- Heart Failure Research
Background:
- Left ventricular diastolic dysfunction (LVDD) can be asymptomatic or present as heart failure with preserved ejection fraction (HFpEF).
- Echocardiographic predictors of symptomatic LVDD remain poorly understood.
Purpose of the Study:
- To identify echocardiographic parameters associated with symptomatic presentation in patients with LVDD.
- To differentiate between asymptomatic LVDD and symptomatic HFpEF using echocardiographic data.
Main Methods:
- A cohort of 330 patients with LVDD was analyzed, divided into asymptomatic and HFpEF groups.
- Exclusion criteria included LVEF <50%, significant valvular disease, chronic lung disease, or renal dysfunction.
- Echocardiographic parameters were compared between groups, with regression analysis to identify predictors of symptomatic state.
Main Results:
- The HFpEF group exhibited higher BMI, increased interventricular septum (IVS) thickness, larger left atrial (LA) diameter and volume index, and elevated E velocity and TR jet velocity.
- Significantly lower lateral e' velocity was observed in the HFpEF group.
- Lateral e' velocity emerged as the strongest independent predictor of symptomatic LVDD, with a cutoff of ≤8.2 cm/s showing 76% sensitivity and 79% specificity.
Conclusions:
- Reduced lateral e' velocity is a significant echocardiographic marker associated with symptomatic LVDD and HFpEF.
- Lateral e' velocity demonstrated a negative correlation with NYHA class in the HFpEF group, further supporting its clinical relevance.
Related Concept Videos
01:17Pathophysiology of Heart Failure
2.6K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
2.6K
01:29Heart Failure II: Pathophysiology
607
Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
607
01:30Heart Failure IV: Classification and Diagnostic Evaluation
251
Heart failure can be classified in various ways, with the most common classifications based on physical activity limitations, disease progression, severity, and treatment strategies.The Functional Classification of Heart Failure divides patients into four categories based on physical activity limitation due to symptom burden.Class I: Patients in this class have cardiac disease but no physical activity limitations. Ordinary activities like walking, climbing stairs, or routine tasks do not cause...
251
01:17Imaging Studies for Cardiovascular System I:Echocardiography
670
Cardiac imaging studies encompass a wide range of noninvasive and minimally invasive techniques designed to visualize the heart's structure and function in detail. One such technique is echocardiography, which uses high-frequency ultrasound waves to produce detailed images of the heart, known as echocardiograms.
Indications: Echocardiography is utilized to diagnose heart failure, valve disorders, and myocardial infarction. It also assesses cardiac structures' size, shape, and motion,...
Indications: Echocardiography is utilized to diagnose heart failure, valve disorders, and myocardial infarction. It also assesses cardiac structures' size, shape, and motion,...
670
01:23Mitral Stenosis II: Clinical features and Diagnostic Tests
167
Mitral stenosis is a heart condition in which the mitral valve, which allows blood to flow from the left atrium to the left ventricle, becomes narrowed or stenotic. This narrowing hinders blood flow and leads to clinical symptoms requiring specific medical evaluations and management strategies. The following overview outlines the clinical symptoms, assessments, diagnostic findings, prevention methods, and treatments for mitral stenosis.Clinical ManifestationsDyspnea (shortness of breath): This...
167
01:29Cardiomyopathy III: Hypertrophic Cardiomyopathy
310
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
310