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High prevalence of parent-reported sleep problems in pediatric patients with acute lymphoblastic leukemia after

Lindsay M H Steur1, Martha A Grootenhuis2, Eus J W Van Someren3,4,5

  • 1Emma Children's Hospital, Amsterdam UMC, Vrije Universiteit Amsterdam, Pediatric Oncology, Cancer Center Amsterdam, Amsterdam, The Netherlands.

Pediatric Blood & Cancer
|January 17, 2020
PubMed

Insights

Pediatric acute lymphoblastic leukemia (ALL) patients experience higher rates of sleep problems post-induction therapy, as reported by parents. Parental distress and sleep issues predict these childhood sleep disturbances.

Area of Science:

  • Pediatric Oncology
  • Sleep Medicine
  • Child Psychology

Background:

  • Pediatric acute lymphoblastic leukemia (ALL) treatment, particularly the intensive induction phase, can significantly impact a child's well-being.
  • Sleep disturbances are common in pediatric cancer patients but require further investigation after intensive therapy.

Purpose of the Study:

  • To determine the prevalence and predictors of sleep problems in pediatric patients with ALL after induction therapy.
  • To compare sleep problem rates in ALL survivors with those in healthy children.

Main Methods:

  • Utilized the Children's Sleep Habits Questionnaire (CSHQ) for parent and self-reports, alongside actigraphy for objective sleep measures.
  • Assessed parental sleep, distress, and parenting challenges using validated questionnaires.
  • Compared sleep problem prevalence (Z-score > 1) in ALL patients to healthy controls and identified determinants of parent-reported sleep issues via regression models.

Main Results:

  • Parents reported sleep problems in 38.0% of ALL patients, significantly higher than the 15.2% in healthy children (P < .001).
  • Actigraphy revealed longer total time in bed and total sleep time in ALL patients compared to controls.
  • Parenting problems, parental sleep issues, bedroom sharing, and child sleep medication use predicted higher parent-reported child sleep problems (27.4% explained variance).

Conclusions:

  • Pediatric ALL survivors exhibit a higher prevalence of sleep problems post-induction therapy, primarily identified through parental reports.
  • Parental factors, including sleep quality and distress, are significant predictors of sleep disturbances in children undergoing ALL treatment.
  • Systematic monitoring and intervention for both child and parental sleep are crucial for improving the quality of life for pediatric ALL survivors.
Abstract

Keywords:
actigraphyacute lymphoblastic leukemiaparentingpediatricquestionnairessleep

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