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Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors
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A Pharmacist-Led, Same-Day, HIV Pre-Exposure Prophylaxis Initiation Program to Increase PrEP Uptake and Decrease Time

Christine M Khosropour1, Kandis V Backus2,3, Arianna R Means4

  • 1Department of Epidemiology, University of Washington, Seattle, Washington.

AIDS Patient Care and Stds
|January 17, 2020
PubMed
Summary
This summary is machine-generated.

A pilot program in Mississippi successfully initiated pre-exposure prophylaxis (PrEP) for HIV prevention among high-risk individuals, particularly Black men who have sex with men (MSM). The on-site pharmacist model improved PrEP access, though retention in care needs enhancement.

Keywords:
HIVpharmacistpre-exposure prophylaxis

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Area of Science:

  • Public Health
  • Infectious Disease Prevention
  • Pharmacology

Background:

  • Mississippi exhibits high HIV rates and low pre-exposure prophylaxis (PrEP) uptake, especially among Black men who have sex with men (MSM) and women.
  • Addressing this disparity requires innovative strategies to increase PrEP accessibility and adherence.

Purpose of the Study:

  • To evaluate the feasibility and effectiveness of same-day PrEP initiation by an on-site clinical pharmacist in a nonclinical HIV testing center.
  • To assess PrEP uptake and retention among high-risk individuals in Jackson, Mississippi.

Main Methods:

  • A pilot program referred HIV-negative, high-risk patients to an on-site pharmacist for immediate PrEP evaluation and prescription.
  • No baseline labs were obtained during pharmacist evaluation; clinical appointments with lab testing were scheduled within 6 weeks.
  • The study population comprised 69 patients, with 57% MSM, 77% Black, and 65% uninsured.

Main Results:

  • All 69 patients received a PrEP prescription, with 97% receiving it within 5 days.
  • 53 (77%) patients filled their prescriptions, 87% within one week.
  • Only 23 (43%) of those who filled prescriptions attended their follow-up clinical appointment within 6 weeks.

Conclusions:

  • An on-site pharmacist in a nonclinical setting can effectively initiate PrEP for predominantly low-income, Black MSM in the Southern US.
  • Improving integration of laboratory testing and enhancing patient retention in care are crucial for future PrEP delivery models.