Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Dose-Response Relationship: Selectivity and Specificity01:25

Dose-Response Relationship: Selectivity and Specificity

9.4K
Drugs exert their therapeutic effects by interacting with receptors, enzymes, or ion channels that are present throughout the human body. The strength and duration of the interaction between a drug and its target receptor are characterized by the selectivity and specificity of the drug. Selectivity refers to a drug's strong preference for its intended target over other targets. For instance, isoprenaline, a non-selective β-adrenergic agonist, interacts with both β1- and...
9.4K
Clinical Trials01:16

Clinical Trials

10.1K
Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
10.1K
Sensitivity, Specificity, and Predicted Value01:13

Sensitivity, Specificity, and Predicted Value

1.1K
In healthcare diagnostics, laboratory tests play a crucial role in identifying and diagnosing a wide range of medical conditions. However, interpreting test results is not always straightforward. An abnormal test result does not always confirm the presence of a disease, just as a normal result does not guarantee its absence. To assess the reliability of these diagnostic tools, healthcare practitioners rely on two key statistical indicators: sensitivity and specificity.
Sensitivity is the...
1.1K
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

347
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
347
Case Studies01:22

Case Studies

13.2K
There are many research methods available to psychologists in their efforts to understand, describe, and explain behavior and the cognitive and biological processes that underlie it.
13.2K
Clinically Relevant Drug Product Specifications: Methods of Establishment01:29

Clinically Relevant Drug Product Specifications: Methods of Establishment

140
Product specifications define the acceptable quality of a pharmaceutical product by ensuring identity, purity, potency, and strength. These specifications serve as benchmarks during development, manufacturing, and post-approval quality control. Clinically relevant specifications are particularly important because they directly relate to a drug's safety and efficacy in clinical use.Dissolution studies are critical biopharmaceutic tools that link in vitro behavior to in vivo performance. They...
140

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

TED Talk: An Innovative Assignment to Learn Research and Evidence-Based Practice Concepts.

Nurse educator·2020
Same author

Interventions to Reduce Perceived Stress Among Graduate Students: A Systematic Review With Implications for Evidence-Based Practice.

Worldviews on evidence-based nursing·2017
Same author

Answering Student Questions During Examinations: A Descriptive Study of Faculty Beliefs.

Nursing education perspectives·2016
Same author

Rolling out the rapid response team.

The American journal of nursing·2013
Same author

Preparing clinical preceptors to support nursing students in evidence-based practice.

Journal of continuing education in nursing·2012
Same author

Evidence-based practice, step by step: sustaining evidence-based practice through organizational policies and an innovative model.

The American journal of nursing·2011

Related Experiment Video

Updated: Dec 30, 2025

Barnes Maze Testing Strategies with Small and Large Rodent Models
12:59

Barnes Maze Testing Strategies with Small and Large Rodent Models

Published on: February 26, 2014

43.3K

Sensitive Versus Specific Search Strategy to Answer Clinical Questions.

Susan B Stillwell, Jane Greer Scott

    The Journal of Nursing Education
    |January 17, 2020
    PubMed
    Summary

    A sensitive search strategy for clinical questions identified more relevant studies than a specific search. This approach is more effective for finding evidence-based practice information in nursing research.

    Area of Science:

    • Nursing Research
    • Evidence-Based Practice
    • Information Science

    Background:

    • Clinicians and students struggle to find evidence for clinical questions.
    • Challenges include database searching skills, confidence, and determining the number of databases to search.
    • Efficient and effective search strategies are crucial for implementing evidence-based practice.

    Purpose of the Study:

    • To compare the effectiveness of specific versus sensitive search strategies in systematic reviews.
    • To evaluate search strategies for answering clinical questions in nursing.

    Main Methods:

    • Replication of a systematic review by Stillwell, Vermeesch, and Scott.
    • Comparison of a specific search strategy with a sensitive search strategy.
    • Analysis of retrieved articles for relevance to a clinical question.

    More Related Videos

    Assessing Specificity of Anticancer Drugs In Vitro
    09:39

    Assessing Specificity of Anticancer Drugs In Vitro

    Published on: March 23, 2016

    9.7K
    Comparing Bibliometric Analysis Using PubMed, Scopus, and Web of Science Databases
    05:02

    Comparing Bibliometric Analysis Using PubMed, Scopus, and Web of Science Databases

    Published on: October 24, 2019

    33.3K

    Related Experiment Videos

    Last Updated: Dec 30, 2025

    Barnes Maze Testing Strategies with Small and Large Rodent Models
    12:59

    Barnes Maze Testing Strategies with Small and Large Rodent Models

    Published on: February 26, 2014

    43.3K
    Assessing Specificity of Anticancer Drugs In Vitro
    09:39

    Assessing Specificity of Anticancer Drugs In Vitro

    Published on: March 23, 2016

    9.7K
    Comparing Bibliometric Analysis Using PubMed, Scopus, and Web of Science Databases
    05:02

    Comparing Bibliometric Analysis Using PubMed, Scopus, and Web of Science Databases

    Published on: October 24, 2019

    33.3K

    Main Results:

    • The specific search yielded 5,108 articles, with 8 relevant.
    • The sensitive search yielded 11,362 articles, with 9 relevant.
    • The sensitive search identified all relevant articles from the specific search plus one additional study.

    Conclusions:

    • A sensitive search strategy is more effective for locating relevant studies for clinical questions.
    • Using PubMed instead of MEDLINE in the specific search would have yielded identical results.
    • Optimizing search strategies enhances the discovery of evidence for nursing practice.