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Updated: Dec 30, 2025
Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier
Published on: February 8, 2017
Construction and application of targeted drug delivery system based on hyaluronic acid and heparin functionalised
Qianqian Duan1, Lan Ma1, Boye Zhang1
1MicroNano System Research Center, Key Lab of Advanced Transducers and Intelligent Control System of the Ministry of Education, College of Information and Computer, Taiyuan University of Technology, Jinzhong, 030600, China.
Abstract:
Thrombosis is a main complication of cancer. It can increase the mortality of cancer patients. Therefore, the anticoagulant heparin (Hep) as an adjuvant therapy was introduced to the drug delivery system based on doxorubicin hydrochloride (DOX)-carbon dots (CDs)-Hyaluronic acid (HA), which obviously enhanced the blood compatibility of the system. Drug release process of the CDs-HA-Hep/DOX system was dual-responsive by HA and pH value. Results of in vitro MTT and scratch tests demonstrated that the drug delivery system could targetedly inhibit growth and migration of cancerous cells. In addition, the system allows visual tracking of the drug based on fluorescence of CDs.
