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Influence of VIP on D-galactose transport across rabbit jejunum in vivo
M J Rodríguez-Yoldi1, M P Arruebo, A I Alcalde
1Departamento de Biomedicina (Fisiología), Facultad de Veterinaria, Zaragoza, Spain.
Revista Espanola De Fisiologia
|June 1, 1988
Abstract:
D-galactose absorption during 1 min perfusion periods was not affected by the presence of 10(-7)-10(-8) M VIP in the sugar solution, but exposure of mucosa to VIP for 5 min inhibited sugar absorption in the subsequent periods of perfusion. This inhibition is reversed after washing with saline solution. The effect of VIP disappeared when 10(-6) M RMI 12330A was added to the incubation solution together with 10(-7) M VIP and 1 mM D-galactose solution. These results suggest the existence of VIP receptors on the brush border membrane. The action of VIP could be mediated through the cAMP system.