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Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2...
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Related Experiment Video

Updated: Dec 30, 2025

Reduced Itraconazole Concentration and Durations Are Successful in Treating Batrachochytrium dendrobatidis Infection in Amphibians
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Itraconazole in dermatology.

Dt Roberts1

  • 1Southern General Hospital, Glasgow, UK.

The Journal of Dermatological Treatment
|January 18, 2020
PubMed
Summary

Itraconazole, a broad-spectrum antifungal, effectively treats various yeast and mould infections, including candidiasis and dermatophytosis. It offers a favorable side-effect profile compared to other systemic antifungals, enabling shorter treatment durations.

Area of Science:

  • Mycology
  • Pharmacology
  • Dermatology

Background:

  • Itraconazole is a triazole antifungal agent.
  • It exhibits broad-spectrum activity against yeasts and moulds.
  • It is effective against various fungal infections, including candidiasis, pityriasis versicolor, and dermatophytosis.

Purpose of the Study:

  • To evaluate the efficacy and tolerability of itraconazole.
  • To compare itraconazole with griseofulvin in treating dermatophytosis.

Main Methods:

  • Clinical evaluation of itraconazole's antifungal activity.
  • Comparative assessment of itraconazole and griseofulvin potency.

Main Results:

  • Itraconazole demonstrates potent fungistatic activity against dermatophytes, surpassing griseofulvin.

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  • It is well-absorbed and associated with fewer side-effects than systemic imidazoles.
  • Effective in various candidal infections and particularly in pityriasis versicolor.

    • Conclusions:

    • Itraconazole is a highly effective antifungal agent for a wide range of fungal infections.
    • Its superior potency allows for shorter treatment periods in dermatophytosis.
    • Favorable side-effect profile makes it a valuable alternative to existing treatments.