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    Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
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    This study introduces a novel magnetic-responsive drug delivery substrate. The smart material controllably releases more vancomycin antibiotic when exposed to specific magnetic fields.

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    Area of Science:

    • Biomaterials Science
    • Nanotechnology
    • Drug Delivery Systems

    Background:

    • Drug delivery systems (DDS) require precise control over drug release kinetics.
    • External stimuli-responsive materials offer potential for targeted and on-demand drug delivery.
    • Chitosan-based hydrogels are biocompatible and widely explored for biomedical applications.

    Purpose of the Study:

    • To develop and characterize a novel DDS responsive to high-frequency alternating magnetic fields.
    • To investigate the controlled release of vancomycin from a magnetic DDS.
    • To evaluate the influence of magnetic field stimuli on drug elution profiles.

    Main Methods:

    • Fabrication of a DDS using chitosan crosslinked with polyethylene glycol dimethacrylate (PEGDMA).
    • Incorporation of Fe3O4 magnetic nanoparticles and vancomycin into the DDS matrix.
    • Application of external magnetic field stimuli (25 mT, 109.9 kHz) to assess vancomycin release over 19 hours.
    • Analysis of vancomycin elution comparing stimulated and non-stimulated samples.
    • Preliminary investigation into the effect of varying PEGDMA chain lengths.

    Main Results:

    • The DDS demonstrated magnetic-field responsiveness, significantly increasing vancomycin release by up to 21% compared to non-stimulated controls.
    • Controlled elution was observed over a 19-hour period with intermittent magnetic stimulation.
    • Preliminary data suggests PEGDMA chain length influences the DDS performance.

    Conclusions:

    • A novel, smart DDS responsive to external magnetic fields has been successfully developed.
    • The DDS enables modulated and controllable antibiotic (vancomycin) elution.
    • This technology holds promise for personalized and on-demand drug delivery applications.