Predicting lymphoma outcomes and risk factors in patients with primary Sjögren's Syndrome using gradient boosting
Abstract:
Primary Sjogren's Syndrome (pSS) is a chronic autoimmune disease followed by exocrine gland dysfunction, where it has been long stated that 5% of pSS patients are prone to lymphoma development. In this work, we use clinical data from 449 pSS patients to develop a first, rule-based, supervised learning model that can be used to predict lymphoma outcomes, as well as, identify prominent features for lymphoma prediction in pSS patients. Towards this direction, the gradient boosting method combined with regression tree ensembles is used to derive a rule-based, decision model for lymphoma prediction. Our results reveal an average accuracy 87.1% and area under the curve score 88%, highlighting the importance of the C4 value, the rheumatoid factor and the lymphadenopathy factor as prominent lymphoma predictors, among others.
More Related Videos
07:25Author Spotlight: A Focus on Standardized Salivary Gland Ultrasound Protocol in Connective Tissue Disease Research
Published on: October 13, 2023
10:21Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
Published on: September 20, 2024
Related Concept Videos
Primary Lymphoid Organs
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
Secondary Lymphoid Organs
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
Cancer Survival Analysis
Sensitivity, Specificity, and Predicted Value
Sensitivity is the...
Lymphoid Cells and Tissues
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
Development of the Lymphatic System
The first lymph sacs to form are the paired jugular lymph sacs located at the junction of the internal jugular and subclavian veins. From these sacs, lymphatic capillary plexuses extend to the thorax, upper limbs, neck, and head, eventually forming lymphatic vessels. Each jugular lymph sac maintains a...
