Related Experiment Video
Updated: Dec 30, 2025
10:10
Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents
Published on: February 15, 2022
1.8K
Disruption of brain network organization in primary open angle glaucoma
Summary
Glaucoma patients show altered brain network organization. Resting-state fMRI reveals significant differences in brain network disruption, suggesting glaucoma impacts the central nervous system.
Area of Science:
- Neuroimaging
- Neuroscience
- Ophthalmology
Background:
- Resting-state functional magnetic resonance imaging (rs-fMRI) is crucial for studying brain connectivity.
- Emerging evidence suggests primary open-angle glaucoma (POAG) may involve central nervous system (CNS) alterations.
- Understanding brain network changes in glaucoma is vital for its classification and treatment.
Purpose of the Study:
- To investigate brain network reorganization in glaucoma patients using graph theory.
- To assess integration, segregation, and centrality using network association measures.
- To evaluate global and local brain network disruption indices in glaucoma.
Main Methods:
- Nineteen glaucoma patients and sixteen controls underwent 3T rs-fMRI.
- rs-fMRI data were preprocessed and parcellated into 116 regions (AAL atlas).
- Graph-theoretical measures and disruption indices were computed using partial correlations.
Main Results:
- A significant negative group-wise disruption index was observed across all graph theoretical metrics.
- Statistically significant group differences were found in subject-wise local disruption indices.
- These findings indicate substantial cerebral reorganization in the brain networks of glaucoma patients.
Conclusions:
- Glaucoma patients exhibit significant alterations in brain network organization.
- The observed cerebral reorganization supports the view of glaucoma as a CNS disease.
- Glaucoma may be classified among disconnection syndromes, highlighting neurodegenerative aspects.
More Related Videos
Related Concept Videos
01:25Glaucoma: Overview
1.2K
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
1.2K
01:27Open Angle Glaucoma: Treatment
905
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
905
01:28Angle Closure Glaucoma: Treatment
1.1K
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
1.1K
01:22Photoreceptors and Visual Pathways
8.5K
At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category,...
8.5K