Abnormal interhemispheric functional interactions in drug-naïve adult-onset first episode psychosis patients

Previous neuroimaging studies have shown that the cortical functional dysconnectivity contributed to the etiology of schizophrenia (SCZ). However, the interhemispheric functional interactions in SCZ remain not fully understood. The clinical heterogeneity of SCZ might lead to the variations in the findings and the effect of medication had a profound influence on the patient's functional features. In this study, we were aimed at investigating the interhemispheric functional interactions in drug-naïve adult-onset first episode psychosis (FEP) patients. Using voxel-mirrored homotopic connectivity (VMHC) analysis for functional magnetic resonance imaging (fMRI) data, we found decreased VMHC values in precuneus, posterior cingulate cortex (PCC), pallidum gyrus, inferior temporal gyrus and superior temporal gyrus in FEP patients. Additionally, the peak VMHC value of PCC was negatively correlated with the PANSS depression factor score. And the peak VMHC value of precuneus was positively correlated with the PANSS positive factor score. The results indicated that the disrupted interhemispheric functional connectivity of posterior default mode network (DMN) was related to emotion and consciousness dysregulation in FEP patients.