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A Priori Sample Size Determination for the Number of Subjects in an EEG Experiment

E Guttmann-Flury, X Sheng, D Zhang

    Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
    |January 18, 2020
    PubMed

    Abstract:

    This paper represents a first attempt to perform a priori sample size determination from a "historic" Electroencephalography (EEG) dataset. The importance of adequate sample size is firstly highlighted, and evidence is given against the use of normal distribution for such computations, when the data cannot be assumed to be Gaussian. The "historic" dataset is then thoroughly examined to determine the least less likely underlying distribution for the desired phenomenon, in this case the spontaneous blinks potential. Two Monte Carlo simulations, using different distribution assumptions, are subsequently computed to estimate the a priori minimum sample size. Finally, these choices are discussed considering practical limitations, as well as the computational differences for other phenomena to study.

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