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High density nanowire electrodes for intracortical microstimulation.

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    Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
    |January 18, 2020
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    Summary

    High-density nanowire electrodes offer enhanced resolution for intracortical microstimulation. These novel electrodes enable precise cortical stimulation with low current, expanding treatment possibilities for neurological dysfunctions.

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    Area of Science:

    • Neuroscience
    • Biomedical Engineering
    • Materials Science

    Background:

    • High-density electrodes are crucial for precise intracortical microstimulation.
    • Current electrode technology faces limitations in resolution and specificity.
    • Nanotechnology offers potential solutions for advanced neural interfaces.

    Purpose of the Study:

    • To fabricate and develop high-density nanowire (NW) electrodes for intracortical microstimulation.
    • To evaluate the efficacy of NW electrodes in stimulating specific cortical regions with low current amplitude.
    • To explore the potential of NW electrodes in expanding microstimulation capabilities for treating neurological disorders.

    Main Methods:

    • Fabrication of high-density nanowire electrodes with nano feature size (~ 2.45×10^9 / cm^2).
    • Intracortical microstimulation experiments using the developed NW electrodes.
    • Assessment of stimulation resolution and specificity at low current amplitudes (120-180 μA).

    Main Results:

    • Successfully fabricated high-density NW electrodes with a density of ~ 2.45×10^9 / cm^2.
    • Demonstrated direct stimulation of specific cortical regions with low current amplitude (120-180 μA).
    • Achieved enhanced resolution and specificity compared to conventional microstimulation techniques.

    Conclusions:

    • The developed high-density nanowire electrodes significantly improve resolution and specificity in intracortical microstimulation.
    • These NW electrodes facilitate precise neural stimulation with minimal current, broadening therapeutic applications.
    • This advancement holds promise for expanding the range of treatable neurological dysfunctions using microstimulation.