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Development of a Low Cost & Low Noise Amplification System For In Vitro Neuronal Recording through Microelectrode

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    Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
    |January 18, 2020
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    Summary

    We developed a low-cost, low-noise amplifier system for microelectrode array recordings. This system enables high-quality neural recordings from electrically active cells at a reduced cost.

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    Area of Science:

    • Neuroscience
    • Biomedical Engineering
    • Electronics

    Background:

    • Effective recording from electrically active cells using microelectrode arrays necessitates specialized amplification and data acquisition systems.
    • Commercially available systems often present high costs and limited customization options for hardware and software.

    Purpose of the Study:

    • To design and construct a low-cost, low-noise amplifier system for microelectrode array recordings.
    • To provide a customizable alternative to expensive commercial systems for neural signal acquisition.

    Main Methods:

    • Developed a low-cost amplifier (US$21/channel) with a gain of 2000, operating from 0-5V DC battery power.
    • Implemented a high-pass filter (0.7 Hz cut-off) to remove electrode-electrolyte interface DC voltage and a 10 kHz bandwidth.
    • Utilized a customized neural interface board to mitigate electromagnetic interference and connected it to a National Instruments analog-to-digital converter.

    Main Results:

    • The amplifier system achieved a low intrinsic noise amplitude of 0.8 μVrms.
    • Demonstrated high-quality in vitro recordings from primary hippocampal neurons.
    • The system offers a cost-effective solution for neural recordings.

    Conclusions:

    • The developed low-cost amplifier system effectively facilitates high-quality neural recordings from microelectrode arrays.
    • This system presents a viable, customizable, and affordable alternative for neuroscience research and applications.