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    Area of Science:

    • Biomedical Optics
    • Medical Imaging Technology
    • Acoustic Physics

    Background:

    • Photoacoustic imaging (PAI) is an emerging technique merging light and ultrasound for imaging.
    • Conventional PAI probes lack adjustable capabilities, limiting illumination flexibility.
    • Standard designs offer fixed light and sound integration, hindering optimized photoacoustic generation.

    Purpose of the Study:

    • To propose and evaluate a novel photoacoustic imaging system featuring a light-adjustable handheld probe.
    • To demonstrate the advantages of adjustable spot size, distance, and illumination schemes (bright-field, dark-field, mixed-field).
    • To explore the selection of different excitation modes for optimizing photoacoustic signal generation.

    Main Methods:

    • Development of a light-adjustable handheld probe for photoacoustic imaging.
    • Implementation of adjustable parameters for spot size and distance control.
    • Utilizing Monte Carlo simulations to analyze light field distributions and excitation advantages.
    • Conducting experimental testing to validate simulation findings and system performance.

    Main Results:

    • The proposed probe allows for adjustable spot size and distance, enabling versatile illumination control.
    • Bright-field, dark-field, and mixed-field illumination schemes can be achieved by tuning parameters.
    • Monte Carlo simulations indicated that different light fields offer distinct advantages for photoacoustic generation.
    • Both simulation and experimental results confirmed the system's effectiveness and potential.

    Conclusions:

    • The developed light-adjustable handheld probe significantly enhances the flexibility of photoacoustic imaging systems.
    • Adjustable illumination schemes and excitation modes optimize photoacoustic signal generation.
    • The proposed system shows great potential for advanced biomedical imaging applications due to its versatile configurations.