Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Remodeling01:40

Bone Remodeling

40.1K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
40.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Experimental evaluation of the electrical power output of an uncemented revision hip stem equipped with a piezoelectric element under various everyday activities.

Medical engineering & physics·2026
Same author

Characterization of the electrode-tissue interface during long-term deep brain stimulation in the 6-OHDA rat model of Parkinson's disease.

Journal of neural engineering·2026
Same author

A validated in vitro approach for low-frequency alternating-current stimulation of stem cells: From electrode characterization to biological responses.

Protoplasma·2026
Same author

Evaluating the electrical stimulation of bone cells based on an induced transmembrane potential model and intracellular calcium levels.

Journal of tissue engineering·2026
Same author

Effects of longer-term pallidal stimulation on the severity of dystonia in a phenotypic animal model.

Experimental neurology·2025
Same author

Review on modeling theories of electrosensitive hydrogels for cartilage tissue engineering.

Frontiers in bioengineering and biotechnology·2025

Related Experiment Video

Updated: Dec 30, 2025

Author Spotlight: Comparing Alveolar and Long Bone Remodeling to Explore OTM Model Potential
05:25

Author Spotlight: Comparing Alveolar and Long Bone Remodeling to Explore OTM Model Potential

Published on: July 21, 2023

1.8K

Numerical Analysis of Electromechanically Driven Bone Remodeling Using the Open-source Software Framework.

Yogesh Deepak Bansod, Ursula van Rienen

    Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
    |January 18, 2020
    PubMed
    Summary

    This study shows that applying electrical stimulation alongside mechanical loads can enhance bone remodeling. This electromechanically driven model accelerates bone mass deposition for potential therapeutic benefits.

    More Related Videos

    Author Spotlight: PEGASOS Tissue Clearing Technique to Visualize Bone Remodeling
    06:51

    Author Spotlight: PEGASOS Tissue Clearing Technique to Visualize Bone Remodeling

    Published on: August 18, 2023

    2.0K
    Author Spotlight: Insights into an Efficient Murine Maxillary Orthodontic Model Protocol
    04:11

    Author Spotlight: Insights into an Efficient Murine Maxillary Orthodontic Model Protocol

    Published on: October 27, 2023

    1.2K

    Related Experiment Videos

    Last Updated: Dec 30, 2025

    Author Spotlight: Comparing Alveolar and Long Bone Remodeling to Explore OTM Model Potential
    05:25

    Author Spotlight: Comparing Alveolar and Long Bone Remodeling to Explore OTM Model Potential

    Published on: July 21, 2023

    1.8K
    Author Spotlight: PEGASOS Tissue Clearing Technique to Visualize Bone Remodeling
    06:51

    Author Spotlight: PEGASOS Tissue Clearing Technique to Visualize Bone Remodeling

    Published on: August 18, 2023

    2.0K
    Author Spotlight: Insights into an Efficient Murine Maxillary Orthodontic Model Protocol
    04:11

    Author Spotlight: Insights into an Efficient Murine Maxillary Orthodontic Model Protocol

    Published on: October 27, 2023

    1.2K

    Area of Science:

    • Biomedical Engineering
    • Computational Biology
    • Orthopedics

    Background:

    • Bone remodeling is a complex process linking bone structure to mechanical forces.
    • Existing numerical models do not fully explain bone remodeling under diverse stimuli.
    • Understanding bone's response to combined stimuli is crucial for therapeutic interventions.

    Purpose of the Study:

    • To implement and evaluate a recently proposed electromechanically driven bone remodeling model.
    • To investigate the effects of combined mechanical and electrical stimuli on bone density distribution.
    • To explore the potential for enhancing bone remodeling through this integrated approach.

    Main Methods:

    • Utilized an open-source software framework for implementing the electromechanically driven bone remodeling model.
    • Employed the finite element method (FEM) for spatial discretization.
    • Applied the Euler scheme for time derivatives in simulations.
    • Studied both a 2D plate model and a femur bone model.

    Main Results:

    • Simulations demonstrated that electrical stimulation alters bone density distribution.
    • A general trend of increased bone mass deposition was observed under electrical stimulation.
    • The model successfully predicted changes in bone morphology due to combined stimuli.

    Conclusions:

    • The electromechanically driven bone remodeling model provides insights into bone adaptation.
    • Simultaneous application of electrical and mechanical stimuli can enhance and accelerate bone remodeling.
    • This approach holds promise for developing novel therapeutic strategies for bone regeneration and repair.