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Cloning of a membrane protein that induces a slow voltage-gated potassium current
T Takumi1, H Ohkubo, S Nakanishi
1Institute for Immunology, Kyoto University Faculty of Medicine, Japan.
Science (New York, N.Y.)
|November 18, 1988
Abstract:
A rat kidney messenger RNA that induces a slowly activating, voltage-dependent potassium current on its expression in Xenopus oocytes was identified by combining molecular cloning with an electrophysiological assay. The cloned complementary DNA encodes a novel membrane protein that consists of 130 amino acids with a single putative transmembrane domain. This protein differs from the known ion channel proteins but is involved in the induction of selective permeation of potassium ions by membrane depolarization.