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Solubility and Bioavailability Enhancement of Oridonin: A Review
Yuanyuan Zhang1, Shaohua Wang1, Mengmeng Dai1
1College of pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China.
Abstract:
Oridonin (ORI), an ent-kaurene tetracyclic diterpenoid compound, is isolated from Chinese herb Rabdosia rubescens with various biological and pharmacological activities including anti-tumor, anti-microbial and anti-inflammatory effects. However, the clinical application of ORI is limited due to its low solubility and poor bioavailability. In order to overcome these shortcomings, many strategies have been explored such as structural modification, new dosage form, etc. This review provides a detailed discussion on the research progress to increase the solubility and bioavailability of ORI.
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