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Uncertain paternity in primate quantitative genetic studies.

Lyle W Konigsberg1, James M Cheverud2

  • 1Department of Anthropology, University of Tennessee, Knoxville.

American Journal of Primatology
|January 18, 2020
PubMed
Summary

Including probabilistic paternal data in primate quantitative genetics studies, specifically craniometric data from macaques, minimally impacts heritability estimates. Significant power gains require a very small number of potential sires per offspring.

Keywords:
Macacaaverage numerator relationship matrixcraniometriesheritability

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Area of Science:

  • Quantitative genetics
  • Primate evolutionary biology
  • Animal breeding

Background:

  • Quantitative genetic studies in primates typically rely on varying levels of known genealogical information.
  • Paternal relationships are often unknown or only partially inferred in wild or semi-wild primate populations.

Purpose of the Study:

  • To evaluate the impact of incorporating probabilistic paternal information on heritability estimates in primate quantitative genetics.
  • To determine the conditions under which including incomplete paternal data significantly enhances the power to detect heritability.

Main Methods:

  • Utilized Henderson's average numerator relationship matrix method.
  • Analyzed craniometric data from the Cayo Santiago macaque colony.
  • Conducted simulation studies to assess the effect of varying numbers of potential sires on heritability detection power.

Main Results:

  • Heritability estimates for craniometric traits were not substantially affected by the addition of incomplete paternal information.
  • A significant increase in the power to detect heritability requires a very small number of equally likely sires per offspring.

Conclusions:

  • The current practice of omitting probabilistic paternal relationships in primate quantitative genetics studies is likely adequate for many scenarios.
  • Substantial improvements in the precision of heritability estimates would necessitate considerable effort in performing paternal exclusions.