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Correlation between PAI-1 rs1799889 polymorphism and venous thromboembolism: A meta-analysis of 48 case-control

Baoyu Geng1, Shenghui Li1, Jungao Zhou1

  • 1Department of Cardiology, Taixing People's Hospital of Jiangsu Province, Taixing, China.

Phlebology
|January 18, 2020
PubMed

Insights

The plasminogen activator inhibitor-1 (PAI-1) rs1799889 polymorphism is linked to venous thromboembolism risk in Caucasians and East Asians. This PAI-1 variant may indicate deep vein thrombosis risk.

Area of Science:

  • Genetics and Molecular Biology
  • Thrombosis Research
  • Epidemiology

Background:

  • Venous thromboembolism (VTE) poses a significant health risk.
  • The role of genetic factors, specifically the plasminogen activator inhibitor-1 (PAI-1) rs1799889 polymorphism, in VTE susceptibility requires further investigation.
  • Understanding genetic predispositions can aid in risk stratification and prevention strategies for VTE.

Purpose of the Study:

  • To conduct a comprehensive meta-analysis assessing the association between the PAI-1 rs1799889 polymorphism and the risk of venous thromboembolism.
  • To identify specific populations or VTE subtypes where this genetic variant may confer increased risk.

Main Methods:

  • A systematic literature search was performed across major scientific databases including PubMed, Medline, Embase, Web of Science, and CNKI.
  • Eligible studies investigating the PAI-1 rs1799889 polymorphism and VTE risk were included.
  • Statistical analysis involved calculating odds ratios (ORs) with 95% confidence intervals (CIs) to quantify the association.

Main Results:

  • The meta-analysis included 48 studies comprising 14,806 participants.
  • Overall analyses did not reveal a significant association between the PAI-1 rs1799889 polymorphism and VTE risk.
  • Subgroup analyses demonstrated a significant association in Caucasian and East Asian populations, and specifically with the risk of deep vein thrombosis (DVT).

Conclusions:

  • The PAI-1 rs1799889 polymorphism may serve as a potential biological marker for venous thromboembolism risk in Caucasian and East Asian individuals.
  • Further research is warranted to elucidate the precise mechanisms underlying this association and its clinical utility in VTE risk assessment.
Abstract

Keywords:
Plasminogen activator inhibitor-1gene polymorphismmeta-analysisvenous thromboembolism

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