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Uncontrolled hypertension among patients with comorbidities in sub-Saharan Africa: protocol for a systematic review

Shukri F Mohamed1,2,3, Olalekan A Uthman4, Rishi Caleyachetty5

  • 1Academic Unit of Primary Care (AUPC) and the NIHR Global Health Research Unit on Improving Health in Slums, University of Warwick, Coventry, UK. Shukri.Mohamed@warwick.ac.uk.

Systematic Reviews
|January 18, 2020
PubMed

Insights

Uncontrolled hypertension is a major cardiovascular risk, especially in sub-Saharan Africa. This review quantifies its prevalence in patients with comorbidities to inform public health strategies.

Area of Science:

  • Cardiology
  • Public Health
  • Epidemiology

Background:

  • Uncontrolled hypertension is a leading cause of cardiovascular disease globally.
  • Sub-Saharan Africa faces the highest prevalence of uncontrolled hypertension, with low treatment rates.
  • Hypertension frequently co-exists with comorbidities, worsening patient outcomes.

Purpose of the Study:

  • To estimate the prevalence of uncontrolled hypertension among patients with comorbidities in sub-Saharan Africa.
  • To provide data for guiding public health policies and interventions in the region.
  • To quantify the burden of uncontrolled hypertension in this vulnerable population.

Main Methods:

  • Systematic review and meta-analysis of published and unpublished studies (2000-2019).
  • Searches of MEDLINE, Embase, and Web of Science; expert consultation; Open SIGLE review.
  • Data extraction and bias assessment by two reviewers, with arbitration by a third; random effects model for meta-analysis.

Main Results:

  • The review will quantify the prevalence of uncontrolled hypertension in patients with comorbidities in sub-Saharan Africa.
  • Results will be stratified by country, comorbidity, and geographic region for detailed insights.
  • Publication bias will be assessed using Egger's test and funnel plots.

Conclusions:

  • This systematic review and meta-analysis will provide crucial data on uncontrolled hypertension prevalence in sub-Saharan Africa.
  • Findings are expected to inform targeted interventions and health policies to mitigate cardiovascular disease risks.
  • The study aims to improve health outcomes for patients with hypertension and comorbidities in the region.
Abstract

Keywords:
ComorbiditiesHypertensionSub-Saharan AfricaUncontrolled hypertension

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