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Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
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Related Experiment Video

Updated: Dec 30, 2025

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
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[Low-grade dural extranodal marginal zone lymphoma].

Florent Marguet1, Maxime Fontanilles2, Elodie Bohers3

  • 1Inserm U1245, service d'anatomie pathologique, UNIROUEN, Normandie Université, CHU de Rouen, 76000 Rouen, France.

Annales De Pathologie
|January 18, 2020
PubMed
Summary

Primary low-grade dural marginal zone lymphoma is a rare, slow-growing cancer. This study presents two cases, highlighting diagnostic features and treatment approaches for this indolent lymphoma.

Keywords:
Biologie moléculaireGènes TNFAIP3 et SOCS1Low-grade extranodal marginal zone lymphomaLymphome extraganglionnaire de la zone marginaleMeningesMolecular biologyMéningeTNFAIP3 and SOCS1 genes

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Area of Science:

  • Oncology
  • Hematology
  • Pathology

Background:

  • Primary low-grade dural marginal zone lymphoma is a rare, indolent B-cell neoplasm.
  • Unlike other marginal zone lymphomas, it is not associated with infectious agents.

Observation:

  • Two cases are presented: a 72-year-old woman and a 36-year-old man, with symptoms including seizures and headaches.
  • Morphological analysis revealed small lymphocytes with specific immunophenotypes (CD20+, CD79a+, BCL2+, CD5-, CD10-).

Findings:

  • Molecular analysis in one patient identified SOCS1 and TNFAIP3 gene deletions, potentially linked to an unfavorable prognosis.
  • The second patient had no identified genetic anomalies and remains disease-free for seven years post-diagnosis.

Implications:

  • Current treatment involves surgery, radiotherapy, and chemotherapy, though standardized schedules are lacking.
  • The 5-year survival rate is high (96.7%), indicating a generally favorable prognosis for this rare lymphoma.